Table 2

Associations between individual characteristics and advanced colorectal neoplasia in a multivariable analysis and development of the score (test set, N=17 979)

Covariates\|	LR test*	Adjusted OR (95% CI)	p Value	Adjusted β coefficient†	Risk score‡
Age group, years	<0.001
40–49		1	0.002	0	0
50–54		1.53 (1.16 to 2.02)	<0.001	0.43	1
55–59		2.29 (1.75 to 3.00)	<0.001	0.83	2
60–66		3.14 (2.40 to 4.12)		1.15	3
Family history of CRC	<0.001
None		1	<0.001	0	0
One first-degree relative with CRC, aged ≥60 years		1.40 (1.17 to 1.67)	<0.001	0.34	1
One first-degree relative with CRC, aged <60 years		1.66 (1.28 to 2.17)	0.008	0.51	2
Two first-degree relatives with CRC		2.11 (1.22 to 3.66)		0.75	2
Sex	<0.001
Female		1	<0.001	0	0
Male		2.14 (1.71–2.67)		0.76	2
Smoking history, pack-years§	<0.001
None		1	0.654	0	0
<10		1.05 (0.86 to 1.27)	0.001	0	0
10–19		1.34 (1.12 to 1.59)	<0.001	0.30	1
≥20		1.60 (1.39 to 1.85)		0.47	1
BMI (kg/m²)	0.033
<25		1	0.192	0	0
25–29		1.14 (0.94 to 1.38)	0.008	0	0
≥30		1.34 (1.08 to 1.67)	0.081	0.30	1 (0)¶
Interaction with male sex**
25–29		0.78 (0.59 to 1.03)	0.031	0
≥30		0.70 (0.51 to 0.97)		−0.35

*LR test, the likelihood ratio test for models with and without the specified covariate.
†Non-significant covariates were assigned β coefficient=0.
‡Model-adjusted coefficients were rounded up to the nearest one-half integer and then multiplied by two to avoid decimals.
§Regardless of current smoking status.
¶1 point for female sex and 0 point for male sex.
**Significant interaction was shown only between male sex and BMI.
BMI, Body Mass Index; CRC, colorectal cancer; LR, likelihood ratio test.