Univariate and multivariate analysis for the selected clinical features of HBV- and non-HBV-related HCC
| HBV+HCC | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p Value* | HR | 95% CI | p Value** | |
| TP53 mutated | 1.94 | 1.07; 3.5 | 0.03 | 2.27 | 1.10; 4.67 | 0.004 |
| AFP (>24 ng/mL) | 1.39 | 0.73; 2.63 | 0.3 | |||
| Edmondson III–IV | 2.26 | 1.17; 4.34 | 0.01 | 1.32 | 0.60; 2.93 | 0.2 |
| Tumour size (>55 mm) | 1.49 | 0.81; 2.7 | 0.2 | |||
| Origin (European) | 0.39 | 0.19; 0.77 | 0.02 | 0.51 | 0.24; 1.08 | 0.02 |
| Portal invasion | 5.17 | 2.55; 10.5 | <0.0001 | 2.91 | 1.26; 6.69 | 0.001 |
| Tumour number (single) | 0.66 | 0.32; 1.34 | 0.25 | |||
| Satellites nodules | 2.02 | 1.11; 3.66 | 0.02 | 1.44 | 0.68; 3.05 | 0.3 |
| Microvascular invasion | 2.2 | 1.22; 4.1 | 0.009 | 2.91 | 0.73; 3.44 | 0.09 |
| Alcohol intake | 0.9 | 0.37; 2.11 | 0.8 | |||
| HBV-HCC | ||||||
| TP53 mutated | 0.80 | 0.43; 1.52 | 0.5 | |||
| AFP (>24 ng/mL) | 1.16 | 0.68; 1.97 | 0.6 | |||
| Edmondson III–IV | 1.72 | 1.03; 2.87 | 0.04 | 1.25 | 0.69; 2.24 | 0.06 |
| Tumour size (>55 mm) | 1.23 | 0.73; 2.04 | 0.4 | |||
| Origin (European) | 1.33 | 0.47; 3.68 | 0.7 | |||
| Portal invasion | 2.78 | 1.48; 5.23 | 0.001 | 2.37 | 1.17; 4.8 | 0.009 |
| Tumour number (single) | 0.88 | 0.44; 1.73 | 0.7 | |||
| Satellites nodules | 1.8 | 1.08; 2.97 | 0.02 | 1.40 | 0.77; 2.55 | 0.3 |
| Microvascular invasion | 1.88 | 1.12; 3.17 | 0.02 | 1.11 | 0.57; 2.16 | 0.4 |
| Alcohol intake | 1.99 | 1.19; 3.31 | 0.008 | 2.06 | 1.22; 3.5 | 0.005 |
p Values obtained from univariate Cox proportional hazards model (*) and ANOVA (**) are shown.
AFP, α-fetoprotein; HCC, hepatocellular carcinoma.