PPI doses and duration and response rates in prospective studies evaluating PPI-REE
| First author, year of publication | Drug, doses | Dosing interval | Duration (weeks) | Histological remission rates after PPI therapy (definition) |
|---|---|---|---|---|
| Peterson, 201030 | Esomeprazole 40 mg | Once daily | 8 | 33% (<5 eos/HPF) 50% (<15 eos/HPF) |
| Molina-Infante, 20114 | Rabeprazole 20 mg | Twice daily | 8 | 50% (<15 eos/HPF) |
| Francis DL, 201247 | Esomeprazole 40 mg | Twice daily | 6 | 61% (average <5 eos/HPF) |
| Moawad, 201331 | Esomeprazole 40 mg | Once daily | 8 | 33% (<7 eos/HPF) |
| Dellon, 20137 | Any of the PPI drugs at 20–40 mg | Twice daily | 8 | 36% (<15 eos/HPF) |
| Vazquez-Elizondo, 201332 | Omeprazole 20 mg | Twice daily | 8 | 25% (<5 eos/HPF) 56% (<15 eos/HPF) |
| Molina-Infante, 20149 | Omeprazole 40 mg | Twice daily | 8 | 43% (<15 eos/HPF) |
| Van Rhijn, 201421 | Esomeprazole 40 mg | Twice daily | 8 | 50% (<15 eos/HPF) |
| Gutiérrez-Junquera, 201533 | Esomeprazole 1 mg/kg/dose | Twice daily | 8 | 47% (<5 eos/HPF) 68.6% (<15 eos/HPF) |
PPI, proton pump inhibitor; REE, responsive oesophageal eosinophilia.