Table 3

Canonical correspondence analyses for determination of per cent variation in the whole, core and rare microbiota between and within the three subject cohorts by clinical variables significant at the p<0.05 level*

Between cohortsWithin Crohn's disease cohortWithin siblings cohortWithin healthy cohort
VariableWholeCoreRareWholeCoreRareWholeCoreRareWholeCoreRare
Age5.376.085.08
Blood concentration of naïve CD4+ T-cells (cells/mL)2.84.153.694.547.348.848.30
Calprotectin1.73.42.74.685.364.634.855.707.10
Gender1.82.45.036.206.049.127.036.314.577.19
Genotype relative risk (GRR)5.14.34.78.566.759.116.5312.545.645.576.265.34
Ileal/colonic involvement*n/an/an/a5.505.874.946.405.81n/an/an/a
Proportion of blood T-cells with memory phenotype (%)2.02.48.715.779.245.196.87
Proportion of CD4+ naïve T-cells expressing β7 integrin (%)3.64.855.845.195.307.815.6010.084.15
Undetermined89.485.987.867.278.464.556.351.649.172.073.071.4
  • *Ileal/colonic involvement in patients with Crohn's disease used as a factor for the corresponding siblings. n/a denotes not applicable for between cohorts or within healthy cohort analyses.