Table 5

Diagnostic yield of different screening protocols in 210 IAR of the FaPaCa cohort

Screening protocolNIAR with pancreatic lesionsIAR with potentially relevant pancreatic lesions*Missed PDAC
All IAR210120 (57%)111
IAR in protocol 1†98‡47 (48%)50
IAR in protocol 2§175‡73 (42%)60
IAR with screening intervals ≥24 months30/210 (14.3%)17 (57%)1/30 (3%)1
  • *Includes PDAC, multifocal PanIN2/3 lesions with/without BD-IPMN or AFL, pNET.

  • †Protocol 1 included MRI+MRCP+EUS every 12 months.

  • ‡63 IAR were also screened with the other protocol during the complete study time.

  • §Protocol 2 consisted of annual MRI+MRCP. EUS was performed at baseline and then every 3 years or in case of suspicious MRI findings.

  • AFL, atypical flat lesion; BD, branch duct; EUS, endoscopic ultrasonography; FaPaCa, the national case collection for familial pancreatic cancer in Germany; IAR, individuals at risk; IPMN, intraductal papillary mucinous neoplasia; MRCP, MR cholangiopancreatography; PanIN, pancreatic intraepithelial neoplasia; PDAC, pancreatic ductal adenocarcinoma; pNET, pancreatic neuroendocrine tumour.