Binding affinity of ligands to wild type and mutant GC-C
| GC-C receptor | ST (Kd, pM) | Uroguanylin (IC50, nM) |
|---|---|---|
| Wild type (non-mutant) | 421±102 | 6.9±1.3 |
| R792S | 340±182 | 5.8±1.9 |
| L775P | 357±153 | 5.2±1.9 |
| K507E | 427±114 | 2±0.9 |
| N850D | 461±77.6 | 5.7±1.1 |
GC-C, guanylate cyclase C; ST, heat-stable enterotoxin.