Table 3

Pancreatic lesions according to pathology in 21 IAR who underwent pancreatic resections

Histopathological lesionsAll IAR
(n=21)
Age at Dx
(years)
FPC2
(n=7)
FPC3
(n=11)
IAR with PALB2 or BRCA2 mutations
(n=3)
PDAC253*, 68+11
pNET148^1
Multifocal PanIN2+PanIN3352*, 64*, 69*12
BD-IPMN with HGD152+1
Multifocal PanIN2+ BD-IPMN with LGD/MGD±AFL647+, 54+, 57, 58*, 61, 70*141
Multifocal PanIN2253°, 67+11
Focal fibrosis+PanIN1b349^, 54°, 60°12
Serous cystadenoma342°, 61°, 61°21
  • Superscripts indicate previous references that reported imaging and pathological results of IAR: +-17; *-16, 17; ^-17, 20; °-8, 16, 17.

  • FPC2, two affected first-degree relatives; FPC3, at least three affected relatives.

  • AFL, atypical flat lesion; BD-IPMN, branch-duct type intrapapillary mucinous neoplasia; FPC, familial pancreatic cancer; IAR, individuals at risk; LGD/MGD/HGD, low-grade, moderate-grade, high-grade dysplasia; PanIN, pancreatic intraepithelial neoplasia; PDAC, pancreatic ductal adenocarcinoma; pNET, pancreatic neuroendocrine tumour.