FHb ≥10 | FC ≥50 | FHb detectable | FHb detectable and/or FC ≥50 | FC ≥200 | FHb detectable and/or FC ≥200 | |
---|---|---|---|---|---|---|
Positivity rate | 23.5% | 62.0% | 58.3% | 80.5% | 25.9% | 66.0% |
CRC (n=28) | ||||||
Number of cases | 28 | 28 | 28 | 28 | 28 | 28 |
True positives | 25 | 23 | 28 | 28 | 13 | 28 |
False negatives | 3 | 5 | 0 | 0 | 15 | 0 |
False positives | 151 | 427 | 409 | 573 | 175 | 464 |
True negatives | 571 | 271 | 313 | 146 | 523 | 254 |
PPV | 14.2% | 5.1% | 6.4% | 4.7% | 6.9% | 5.7% |
NPV | 99.5% | 98.2% | 100% | 100% | 97.2% | 100% |
Sensitivity | 89.3% | 82.1% | 100% | 100% | 46.4% | 100% |
Specificity | 79.1% | 38.8% | 43.4% | 20.3% | 74.9% | 35.4% |
HRA (n=41) | ||||||
Number of cases | 40* | 41 | 40 | 41 | 41 | 40 |
True positives | 20 | 24 | 33 | 38 | 8 | 34 |
False negatives | 20 | 17 | 7 | 3 | 33 | 6 |
False positives | 156 | 426 | 404 | 563 | 180 | 458 |
True negatives | 554 | 259 | 306 | 143 | 505 | 248 |
PPV | 11.4% | 5.3% | 7.6% | 6.3% | 4.3% | 6.9% |
NPV | 96.5% | 93.8% | 97.8% | 97.9% | 93.8% | 97.6% |
Sensitivity | 50.0% | 58.5% | 82.5% | 92.7% | 19.5% | 85.0% |
Specificity | 78.0% | 37.8% | 43.1% | 20.3% | 73.7% | 35.1% |
IBD (n=34) | ||||||
Number of cases | 34 | 32* | 34 | 34 | 32 | 34 |
True positives | 25 | 29 | 29 | 33 | 23 | 31 |
False negatives | 9 | 3 | 5 | 1 | 9 | 3 |
False positives | 151 | 421 | 408 | 568 | 165 | 461 |
True negatives | 565 | 273 | 308 | 145 | 529 | 251 |
PPV | 14.2% | 6.4% | 6.7% | 5.5% | 12.2% | 6.3% |
NPV | 98.4% | 98.9% | 98.4% | 99.3% | 98.3% | 98.8% |
Sensitivity | 73.5% | 90.6% | 85.3% | 97.1% | 71.9% | 91.2% |
Specificity | 78.9% | 39.3% | 43.0% | 20.3% | 76.2% | 35.3% |
CRC+HRA+IBD | ||||||
Number of cases | 102 | 101* | 102 | 103 | 101 | 102 |
True positives | 70 | 76 | 90 | 99 | 44 | 93 |
False negatives | 32 | 25 | 12 | 4 | 57 | 9 |
False positives | 106 | 374 | 347 | 502 | 144 | 399 |
True negatives | 542 | 251 | 301 | 142 | 481 | 245 |
PPV | 39.8% | 16.9% | 20.6% | 16.5% | 23.4% | 18.9% |
NPV | 94.4% | 90.9% | 96.2% | 97.3% | 89.4% | 96.5% |
Sensitivity | 68.6% | 75.2% | 88.2% | 96.1% | 43.6% | 91.2% |
Specificity | 83.6% | 40.2% | 46.4% | 22.0% | 77.0% | 38.0% |
*One case of HRA had FHb sample unsuitable for analysis. Two cases of IBD had FC samples unsuitable for analysis.
NPV, negative predictive value.