Serum microRNAs (miRs) that are significantly different between discordant twins
| Twin with NAFLD (MRI-PDFF ≥5%) | Twin without NAFLD (MRI-PDFF <5%) | p Value | |
|---|---|---|---|
| N | 18 (6 concordant twin-pairs; 6 individuals in discordant twin-pairs) | 62 (28 concordant twin-pairs; 6 individuals in discordant twin-pairs) | NA |
| miR-331-3p | 7.71 (±0.19) | 8.18 (±0.21) | 0.0039 |
| let-7c | 0 (±0) | 2.78 (±0.6) | 0.0056 |
| miR-30c | 10.15 (±0.22) | 10.87 (±0.24) | 0.0080 |
| miR-146b | 6.56 (±0.17) | 6.96 (±0.19) | 0.013 |
| miR-30b | 10.29 (±0.16) | 10.76 (±0.23) | 0.017 |
| miR-223* | 3.22 (±0.42) | 2.6 (±0.52) | 0.022 |
| miR-126 | 9.57 (±0.38) | 10.49 (±0.21) | 0.023 |
| miR-150 | 10.47 (±0.15) | 11.45 (±0.31) | 0.031 |
| miR-139-5p | 6.16 (±0.19) | 6.79 (±0.24) | 0.038 |
| miR-642 | 2.06 (±0.15) | 2.78 (±0.15) | 0.040 |
A paired t test was used for all comparisons.
MRI-PDFF, MRI-estimated proton-density fat fraction; NA, not applicable; NAFLD, non-alcoholic fatty liver disease.