Characteristics of all morphologically clinically relevant lesions detected at baseline screening with EUS and MRI (n=11)
| Lesion no. | Case no. | Gender, age | Genetic background (no. of affected family members with PDAC) | Tobacco use, alcohol use | Lesion type | Detection test(s) | Size EUS/size MRI (mm) | Location on EUS/location on MRI | Remark | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|
| #1 | 1 | Female, 52 | CDKN2A (7) | Current smoker (23 pack years), no alcohol use | Solid | EUS (radial) | 11/NA | Body/NA | Also in retrospect, the lesion was not visible on MRI | Distal pancreatectomy with splenectomy, pathology: 12 mm T1N0M0 PDAC |
| #2 | 2 | Male, 56 | FPC (2) | No tobacco use, no alcohol use | Solid | EUS (radial) | 7/NA | Head/NA | Due to respiratory motion, the T2 sequence of MRI was of poor quality | Pancreaticoduodenectomy, pathology: multifocal PanIN2 |
| #3 | 3 | Female, 55 | FPC (3) | No tobacco use, no alcohol use | Cystic | MRI and EUS (radial) | 14/17 | Head/head | Unchanged at FU 12 months | |
| #4 | 4 | Female, 62 | LKB1 (0) | Past smoker (20 pack-years), current alcohol use (2 units per week) | Cystic | MRI and EUS (radial) | 6/18 | Head/head | Endosonographist mentioned at baseline investigation that lesion would probably be >6 mm because of elongated appearance | Again detected by both EUS (linear) and MRI at FU 12 months, EUS then described it as 20 mm |
| #5 | 5 | Male, 45 | FPC (3) | Past smoker (16 pack-years), current alcohol use (1 unit per week) | Cystic | MRI and EUS (radial) | 27/36 | Head/head | Diagnosed as pseudocyst (history of acute pancreatitis) | Regression of the pseudocyst |
| #6 | 6 | Male, 49 | CDKN2A (2) | Past smoker (17 pack-years), current alcohol use (7 units per week) | Cystic | MRI and EUS (linear) | 12/12 | Body/body | Unchanged at FU 12 months | |
| #7 | 6 | Male, 49 | CDKN2A (2) | Past smoker (17 pack-years), current alcohol use (7 units per week) | Cystic | MRI and EUS (linear) | 12/13 | Tail/tail | Same patient as #6 | Unchanged at FU 12 months |
| #8 | 7 | Female, 54 | FPC (2) | No tobacco use, no alcohol use | Cystic | MRI and EUS (linear) | 5/10 | Tail/tail | At FU 12 months measured at 3 mm by linear EUS and 5 mm by MRI | |
| #9 | 8 | Male, 69 | FPC (2) | Past smoker (20 pack-years), current alcohol use (3 units per week) | Cystic | MRI | NA/24 | NA/head | Baseline and FU 12 months EUS was performed using a radial scope | At FU 12 months unchanged MRI findings, then also detected by radial EUS (8 mm) |
| #10 | 8 | Male, 69 | FPC (2) | Past smoker (20 pack-years), current alcohol use (3 units per week) | Cystic | MRI | NA/12 | NA/body | Same patients as #9; baseline and FU 12 months EUS was performed using a radial scope | At FU 12 months unchanged MRI findings, then also detected by radial EUS (8 mm) |
| #11 | 9 | Male, 74 | FPC (3) | No tobacco use, current alcohol use (1 unit per week) | Cystic | MRI | NA/10 | NA/head | MRI described lesion in uncinate process, this area could not be visualised by EUS (radial) | At FU 12 months unchanged MRI findings, again not detected by radial EUS |
EUS, endoscopic ultrasonography; FPC, familial pancreatic cancer; FU, follow-up; PanIN, pancreatic intraepithelial neoplasia; PDAC, pancreatic ductal adenocarcinoma.