Table 2

Characteristics of all morphologically clinically relevant lesions detected at baseline screening with EUS and MRI (n=11)

Lesion no.Case no.Gender, ageGenetic background (no. of affected family members with PDAC)Tobacco use, alcohol useLesion typeDetection test(s)Size EUS/size MRI (mm)Location on EUS/location on MRIRemarkOutcome
#11Female, 52CDKN2A (7)Current smoker (23 pack years), no alcohol useSolidEUS (radial)11/NABody/NAAlso in retrospect, the lesion was not visible on MRIDistal pancreatectomy with splenectomy, pathology: 12 mm T1N0M0 PDAC
#22Male, 56FPC (2)No tobacco use, no alcohol useSolidEUS (radial)7/NAHead/NADue to respiratory motion, the T2 sequence of MRI was of poor qualityPancreaticoduodenectomy, pathology: multifocal PanIN2
#33Female, 55FPC (3)No tobacco use, no alcohol useCysticMRI and EUS (radial)14/17Head/headUnchanged at FU 12 months
#44Female, 62LKB1 (0)Past smoker (20 pack-years), current alcohol use (2 units per week)CysticMRI and EUS (radial)6/18Head/headEndosonographist mentioned at baseline investigation that lesion would probably be >6 mm because of elongated appearanceAgain detected by both EUS (linear) and MRI at FU 12 months, EUS then described it as 20 mm
#55Male, 45FPC (3)Past smoker (16 pack-years), current alcohol use (1 unit per week)CysticMRI and EUS (radial)27/36Head/headDiagnosed as pseudocyst (history of acute pancreatitis)Regression of the pseudocyst
#66Male, 49CDKN2A (2)Past smoker (17 pack-years), current alcohol use (7 units per week)CysticMRI and EUS (linear)12/12Body/bodyUnchanged at FU 12 months
#76Male, 49CDKN2A (2)Past smoker (17 pack-years), current alcohol use (7 units per week)CysticMRI and EUS (linear)12/13Tail/tailSame patient as #6Unchanged at FU 12 months
#87Female, 54FPC (2)No tobacco use, no alcohol useCysticMRI and EUS (linear)5/10Tail/tailAt FU 12 months measured at 3 mm by linear EUS and 5 mm by MRI
#98Male, 69FPC (2)Past smoker (20 pack-years), current alcohol use (3 units per week)CysticMRINA/24NA/headBaseline and FU 12 months EUS was performed using a radial scopeAt FU 12 months unchanged MRI findings, then also detected by radial EUS (8 mm)
#108Male, 69FPC (2)Past smoker (20 pack-years), current alcohol use (3 units per week)CysticMRINA/12NA/bodySame patients as #9; baseline and FU 12 months EUS was performed using a radial scopeAt FU 12 months unchanged MRI findings, then also detected by radial EUS (8 mm)
#119Male, 74FPC (3)No tobacco use, current alcohol use (1 unit per week)CysticMRINA/10NA/headMRI described lesion in uncinate process, this area could not be visualised by EUS (radial)At FU 12 months unchanged MRI findings, again not detected by radial EUS
  • EUS, endoscopic ultrasonography; FPC, familial pancreatic cancer; FU, follow-up; PanIN, pancreatic intraepithelial neoplasia; PDAC, pancreatic ductal adenocarcinoma.