Pathways regulated by the 18 microRNAs differentially expressed in alcoholic hepatitis
| Ingenuity canonical pathways | p Value | Genes |
|---|---|---|
| PXR/RXR activation | 2×10−8 | NR1I3,PPARGC1A,RXRA,GSTA2,PRKAG2,HNF4A,CYP2C19,AKT2,FOXO1,FOXO3,CYP2A6 |
| FXR/RXR activation | 3.4×10−7 | PKLR,SLC10A1,SLC22A7,NR5A2,AKT2,PPARGC1A,CLU,RXRA,LCAT,HNF4A,FGFR4,FOXO1,CYP27A1 |
| IGF-1 signalling | 4.8×10−5 | STAT3,IRS2,IRS1,PRKAG2,MAP2K1,AKT2,FOXO1,IGF1,FOXO3 |
| AMPK signalling | 7.4×10−5 | IRS2,PPARGC1A,SMARCA2,ACACB,IRS1,PRKAG2,HNF4A,AKT2,FOXO1,FOXO3,PPP2R5C,ADRA1A |
| Wnt/β-catenin signalling | 1.9×10−4 | CTNNB1,TGFBR3,SOX5,TLE1,LRP6,TCF7L2,NR5A2,AKT2,PPP2R5C,FZD5,ACVR2B |
| PPARα/RXRα activation | 3×10−4 | ADCY1,PPARGC1A,TGFBR3,RXRA,IRS1,PRKAG2,NCOR1,CYP2C19,ACAA1,MAP2K1,ACVR2B |
| PTEN signalling | 0.001 | BCL2L11,TGFBR3,MAGI1,FGFR4,MAP2K1,AKT2,FOXO1,FOXO3 |
| Glucocorticoid receptor signalling | 0.001 | TAF15,SMARCA2,NR3C2,PRKAG2,MAP2K1,AKT2,VCAM1,NFATC3,STAT3,TSC22D3,CEBPB,NCOR1,FOXO3 |
| PI3K signalling in B lymphocytes | 0.002 | NFATC3,ITPR2,IRS2,CAMK2D,IRS1,MAP2K1,AKT2,FOXO3 |
| Leptin signalling in obesity | 0.002 | ADCY1,STAT3,PRKAG2,MAP2K1,AKT2,FOXO1 |
| Molecular mechanisms of cancer | 0.002 | BRCA1,BCL2L11,CTNNB1,CAMK2D,IRS1,PRKAG2,MAP2K1,RAP1A,AKT2,FZD5,ADCY1,RHOB,LRP6,XIAP,FOXO1 |
| Hepatic cholestasis | 0.002 | ADCY1,SLC10A1,SLC22A7,RXRA,PRKAG2,HNF4A,FGFR4,NR5A2,CYP27A1 |
| Dopamine receptor signalling | 0.002 | ADCY1,PPP1R10,PRKAG2,MAOB,PPP2R5C,QDPR |
| Insulin receptor signalling | 0.002 | PPP1R10,IRS2,IRS1,PRKAG2,MAP2K1,AKT2,FOXO1,FOXO3 |
| Xenobiotic metabolism signalling | 0.003 | NR1I3,CHST13,PPARGC1A,CAMK2D,RXRA,GSTA2,CYP2C19,MAF,MAP2K1,MAOB,PPP2R5C,CITED2 |
| Epithelial adherens junction signalling | 0.004 | CTNNB1,TGFBR3,MAGI1,TCF7L2,WASL,RAP1A,AKT2,ACVR2B |
| LPS/IL-1-mediated inhibition of RXR function | 0.005 | NR1I3,CHST13,PPARGC1A,SLC10A1,RXRA,GSTA2,CYP2C19,NR5A2,MAOB,CYP2A6 |
AMPK, adenosine monophosphate-activated protein kinase; FXR, farnesoid x receptor; IGF, insulin-like growth factor; LPS, lipopolysaccharide; PPAR, peroxisome proliferator-activated receptor; PTEN, phosphatase and tensin homolog; RXR, retinoid x receptor.