Table 5

Clinicopathological features associated with CRC in patients with SPS (univariate analysis)

VariableCRC
N=47 (15.8%)
No CRC
N=249 (84.2%)
p value
Demographic and clinical features
 Age at SPS diagnosis: years, mean±SD56.8±8.856.9±10.20.342
 Female, n (%)22 (46.8)108 (43.4)0.664
  BMI*, mean±SD27.1±5.127.7±4.50.425
 Overweight/obesity (BMI ≥25), n (%)22/39 (56.4)124/171 (72.5)0.051
 Smoking history†, n (%)30/45 (66.7)177/233 (76)0.193
 First-degree relative with CRC, n (%)9 (19)78 (31)0.097
 First-degree relative with SPS, n (%)1 (2)12(4)0.376
 SPS WHO criteria‡, n (%)
  ▸ Patients who fulfil criterion I28 (59.6)134 (46.2)0.468
  ▸ Patients who fulfil criterion III33 (70.2)185 (74.3)0.560
  ▸ Patients who fulfil criteria I and III14 (29.8)70 (28.1)0.815
 Follow-up time (months), median (IQR)48 (24–79)44 (26–80)0.843
 Number of colonoscopies, median (IQR)3 (2–4)3 (2–4)0.315
Cumulative number of polyps (per patient), median (IQR)
Serrated polyps
Serrated polyps26 (13–42)26 (19–40)0.326
 Location
  ▸ Proximal to splenic flexure9 (4–16)7 (4–13)0.107
  ▸ Proximal to sigmoid colon12 (5–28)11 (6–19)0.169
  ▸ Rectosigmoid7 (4–21)12 (5–24)0.396
 Size ≥10 mm3 (0–6)2 (0–4)0.054
 Specific subtype of serrated polyp
  ▸ Sessile serrated adenoma/polyp4 (1–14)2 (0–8)0.040
  ▸ Hyperplastic polyp8 (0–24)19 (8–33)0.277
  ▸ Traditional serrated adenoma0 (0–0)0 (0–0)0.516
 Serrated polyps with dysplasia
  ▸ Any dysplasia0 (0–1)0 (0–1)0.496
  ▸ Low-grade dysplasia0 (0–1)0 (0–1)0.961
  ▸ High-grade dysplasia0 (0–0)0 (0–0)0.075
 Combined features§
  ▸ SSA/Ps proximal to splenic flexure3 (0–11)1 (0–4)0.005
  ▸ SSA/P with high-grade dysplasia0 (0–0)0 (0–0)0.041
  ▸ Proximal (to splenic flexure) SSA/P with high-grade dysplasia0 (0–0)0 (0–0)0.016
Adenomas
 Number of adenomas3 (1–6)3 (1–6)0.906
 Number of advanced adenomas¶1 (0–1)0 (0–1)0.910
  • Statistically significant results are represented in bold. *Data concerning BMI were available for 207 patients.

  • †Smoking history includes both active and former smokers. Data concerning smoking history were available for 210 patients.

  • ‡SPS WHO criteria: (I) patients who fulfil criterion I (regardless of criteria II and III); (III) patients who fulfil criterion III (regardless of criteria I and II); (I+III) patients who fulfil both criteria I and III (regardless of criterion II).

  • §Other variables related to SP combination features are widely reported in online supplementary table S1.

  • ¶Adenomas ≥10 mm in diameter or with villous structure or with high-grade dysplasia.

  • BMI, body mass index; CRC, colorectal cancer; SP, serrated polyp; SPS, serrated polyposis syndrome; SSA/P, sessile serrated adenoma/polyp.