CRC risk groups in patients with SPS according to independent CRC risk factors
| Variable | OR | 95% CI | p value |
|---|---|---|---|
| No proximal SSA/P with HGD and ≤2 proximal SSA/Ps | 1* | – | – |
| Any proximal SSA/P with HGD or >2 proximal SSA/Ps | 1.98 | 1.02 to 3.81 | 0.04† |
| Any proximal SSA/P with HGD and >2 proximal SSA/Ps | 4.27 | 1.30 to 14.03 | 0.01† |
| No proximal SSA/P with HGD and ≤2 proximal SSA/Ps | 0.45 | 0.24 to 0.86 | 0.01‡ |
Proximal location refers to the splenic flexure.
*Reference category.
†Compared with the reference category.
‡Compared with patients fulfilling either of the two risk factors.
CRC, colorectal cancer; HGD, high-grade dysplasia; SPS, serrated polyposis syndrome; SSA/P, sessile serrated adenoma/polyp.