Clinical phenotypes associated with Crohn's disease (CD) subclasses
| Paediatric (ileum) | Adult (colon) | |||||
|---|---|---|---|---|---|---|
| Phenotype | Ileum-like (n=50) | Colon-like (n=50) | p Value | Ileum-like (n=10) | Colon-like (n=11) | p Value |
| Location | ||||||
| Ileum-only | 10 | 10 | 1 | 2 | 0 | 0.21 |
| Colon-only | 21 | 11 | 0.0528 | 1 | 6 | 0.06 |
| Ileum+colon | 19 | 29 | 0.0014 | 7 | 5 | 0.39 |
| Patient characteristics | ||||||
| Mean age | 12.1 | 12.4 | 0.6193 | 35.1 | 35.3 | 0.98 |
| Male | 28 | 29 | 1 | 3 | 3 | 1 |
| Female | 22 | 21 | 1 | 7 | 8 | 1 |
| Smoker | NA | NA | NA | 5 | 4 | 0.67 |
| Inflammation | ||||||
| Macroscopic | 29 | 41 | 0.0156 | NA | NA | NA |
| Microscopic | 8 | 6 | 0.7742 | NA | NA | NA |
| None | 13 | 3 | 0.0122 | NA | NA | NA |
| Phenotypes and involvement | ||||||
| Deep ulcers | 10 | 29 | 0.0002 | NA | NA | NA |
| Perianal | NA | NA | NA | 0 | 4 | 0.09 |
| Sigmoid | NA | NA | NA | 2 | 7 | 0.08 |
| Rectal | NA | NA | NA | 0 | 9 | <0.01 |
| Ileal disease | 29 | 39 | 0.0528 | 9 | 5 | 0.06 |
| Inflammatory | NA | NA | NA | 1 | 4 | 0.31 |
| Stricturing | NA | NA | NA | 7 | 4 | 0.2 |
| Penetrating | NA | NA | NA | 5 | 4 | 0.67 |
| Preoperative treatment history | ||||||
| Steroids | NA | NA | NA | 8 | 10 | 0.59 |
| 5-ASA | NA | NA | NA | 8 | 10 | 0.59 |
| Immunomodulation | NA | NA | NA | 8 | 8 | 1 |
| Anti-TNF | NA | NA | NA | 7 | 10 | 0.31 |
| Non-anti-TNF biologic | NA | NA | NA | 0 | 2 | 0.48 |
| Postoperative outcome | ||||||
| Postoperative disease recurrence | NA | NA | NA | =2/8 | =0/10 | 0.18 |
| Postoperative biologic use | NA | NA | NA | =6/9 | =1/11 | 0.02 |
| Colectomy | NA | NA | NA | 0 | 6 | 0.01 |
| Second resection | NA | NA | NA | 3 | 6 | 0.39 |
| Median time to first resection (years) | NA | NA | NA | 3 | 5 | 0.91 |
| Median time from first to second resection (years, if applicable) | NA | NA | NA | 3.5 | 2 | 0.33 |
Paediatric and adult patient phenotypes, segregated by colon-like and ileum-like classifications, were compared using Fisher's exact test (for categorical data) or two-sided t-test (for continuous data). Significant associations (p<0.05) are bolded. See online supplementary tables S2 and S3 for data on individual patients.
5-ASA, 5-aminosalicylic acid; TNF, tumour necrosis factor; NA, not available.