Estimates (with 95% CIs) of effect size for VAS, MRS, GS and RHI based on treatment allocation, MBS and Mayo score definitions as criteria for change
| Treatment Allocation | Absolute change in MBS of at least 1 point | Absolute change in sum of MCS rectal bleeding+stool frequency subscores of at least 2 points | ||||
|---|---|---|---|---|---|---|
| SES | GRS | SES | GRS | SES | GRS | |
| VAS | 0.80 (0.58 to 1.03) | 0.74 (0.52 to 0.97) | 0.75 (0.52 to 0.98) | 0.67 (0.45 to 0.89) | 0.91 (0.67 to 1.16) | 0.85 (0.61 to 1.09) |
| MRS | 1.29 (1.02 to 1.56) | 0.88 (0.65 to 1.12) | 0.94 (0.69 to 1.18) | 0.85 (0.61 to 1.08) | 1.24 (0.96 to 1.52) | 0.91 (0.66 to 1.16) |
| GS | ||||||
| (0) Structural—architectural change | 0.33 (0.13 to 0.54) | 0.28 (0.08 to 0.49) | 0.33 (0.12 to 0.53) | 0.35 (0.14 to 0.56) | 0.32 (0.11 to 0.53) | 0.38 (0.16 to 0.59) |
| (1) Chronic inflammatory infiltrate | 1.34 (1.06 to 1.62) | 0.82 (0.58 to 1.05) | 1.11 (0.85 to 1.36) | 1.15 (0.89 to 1.41) | 1.32 (1.03 to 1.60) | 0.99 (0.73 to 1.25) |
| (2a) Lamina propria eosinophils | 0.28 (0.07 to 0.48) | 0.32 (0.11 to 0.52) | 0.31 (0.10 to 0.51) | 0.33 (0.13 to 0.54) | 0.35 (0.14 to 0.56) | 0.34 (0.13 to 0.55) |
| (2b) Lamina propria neutrophils | 0.76 (0.53 to 0.99) | 0.68 (0.46 to 0.91) | 0.61 (0.39 to 0.83) | 0.49 (0.27 to 0.70) | 0.79 (0.55 to 1.03) | 0.62 (0.40 to 0.85) |
| (3) Neutrophils in epithelium | 1.14 (0.88 to 1.40) | 0.91 (0.67 to 1.15) | 0.90 (0.66 to 1.14) | 1.02 (0.77 to 1.27) | 1.00 (0.75 to 1.25) | 0.81 (0.57 to 1.05) |
| (4) Crypt destruction | 0.70 (0.47 to 0.92) | 0.70 (0.48 to 0.93) | 0.53 (0.31 to 0.74) | 0.56 (0.34 to 0.77) | 0.67 (0.44 to 0.90) | 0.61 (0.39 to 0.84) |
| (5) Erosion or ulceration | 0.56 (0.34 to 0.77) | 0.43 (0.22 to 0.64) | 0.40 (0.19 to 0.61) | 0.25 (0.04 to 0.45) | 0.59 (0.36 to 0.81) | 0.45 (0.24 to 0.67) |
| Total—5-point scale | 1.87 (1.54 to 2.20) | 1.23 (0.97 to 1.50) | 1.31 (1.04 to 1.59) | 1.12 (0.87 to 1.38) | 1.71 (1.39 to 2.04) | 1.29 (1.01 to 1.57) |
| RHI | 1.05 (0.79 to 1.30) | 0.88 (0.64 to 1.12) | 0.81 (0.58 to 1.05) | 0.73 (0.50 to 0.96) | 1.05 (0.78 to 1.31) | 0.84 (0.59 to 1.09) |
GRS, Guyatt's responsiveness statistic; GS, Geboes score; MBS, modified Baron Score; MCS, Mayo Clinic score; MRS, modified Riley score; RHI, Robarts Histopathology Index; SES, standardised effect size; VAS, visual analogue score.