Associations between IBS, IBS subtypes and TRPM8 SNPs
| MA(F)† | IBS (GWAS+this study)* | IBS subtypes (this study)* | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GWAS (534/4932) | Replication (386/357) | Meta-analysis (920/5289) | IBS-D (127/357) | IBS-C (95/357) | IBS-M (163/357) | IBS-C+M (258/357) | |||||||||
| SNP | p Value | OR | p Value | OR | p Value | OR | p Value | OR | p Value | OR | p Value | OR | p Value | OR | |
| rs10519356 | T(0.083) | 5.1E-03 | 1.35 | 1.3E-01 | 1.36 | 1.5E-03 | 1.35 | 9.0E-01 | 0.96 | 4.4E-02 | 1.79 | 8.5E-02 | 1.52 | 3.4E-02 | 1.59 |
| rs10166942 | C(0.196) | 9.5E-03 | 1.23 | 9.2E-04 | 1.62 | 1.3E-04 | 1.30 | 3.8E-01 | 1.19 | 6.7E-03 | 1.83 | 2.8E-04 | 1.90 | 5.1E-05 | 1.91 |
| rs2362290 | A(0.196) | 9.0E-03 | 1.23 | 7.3E-04 | 1.64 | 1.1E-04 | 1.31 | 3.5E-01 | 1.21 | 5.6E-03 | 1.86 | 2.3E-04 | 1.92 | 3.9E-05 | 1.94 |
| rs1003757 | A(0.087) | 4.3E-03 | 1.35 | 1.2E-01 | 1.37 | 1.1E-03 | 1.35 | 8.3E-01 | 0.94 | 5.3E-02 | 1.73 | 6.9E-02 | 1.54 | 2.7E-02 | 1.61 |
| rs1003756 | T(0.087) | 4.3E-03 | 1.35 | 1.2E-01 | 1.37 | 1.2E-03 | 1.35 | 8.3E-01 | 0.94 | 5.3E-02 | 1.73 | 6.9E-02 | 1.54 | 2.7E-02 | 1.61 |
| rs4497869 | A(0.107) | 1.2E-02 | 1.28 | 3.2E-02 | 1.48 | 1.3E-03 | 1.32 | 6.2E-01 | 1.14 | 3.9E-02 | 1.73 | 3.1E-02 | 1.60 | 1.1E-02 | 1.66 |
| rs6431648 | A(0.208) | 5.0E-03 | 1.24 | 4.0E-04 | 1.65 | 3.9E-05 | 1.32 | 2.3E-01 | 1.26 | 8.9E-03 | 1.75 | 2.4E-04 | 1.88 | 3.9E-05 | 1.90 |
| rs758277 | T(0.430) | 6.1E-03 | 0.83 | 6.7E-01 | 0.95 | 9.6E-03 | 0.86 | 2.8E-01 | 1.18 | 2.7E-01 | 0.82 | 3.9E-01 | 0.88 | 1.9E-01 | 0.84 |
| rs758276 | G(0.207) | 5.6E-03 | 1.24 | 4.9E-04 | 1.64 | 4.9E-05 | 1.32 | 2.2E-01 | 1.27 | 8.7E-03 | 1.75 | 4.3E-04 | 1.83 | 6.0E-05 | 1.87 |
| rs758275 | G(0.206) | 5.5E-03 | 1.24 | 5.4E-04 | 1.63 | 5.0E-05 | 1.32 | 2.2E-01 | 1.27 | 1.1E-02 | 1.73 | 4.3E-04 | 1.83 | 7.0E-05 | 1.86 |
| rs6711120 | A(0.208) | 6.0E-03 | 1.24 | 4.9E-04 | 1.64 | 5.2E-05 | 1.32 | 2.2E-01 | 1.27 | 8.7E-03 | 1.75 | 4.3E-04 | 1.83 | 6.0E-05 | 1.87 |
| rs9646720 | G(0.204) | 5.0E-03 | 1.25 | 1.0E-03 | 1.60 | 5.9E-05 | 1.32 | 2.2E-01 | 1.28 | 2.7E-02 | 1.62 | 5.9E-04 | 1.82 | 1.9E-04 | 1.80 |
| rs7595960 | A(0.110) | 6.5E-03 | 1.29 | 3.5E-02 | 1.48 | 7.5E-04 | 1.33 | 6.0E-01 | 1.14 | 4.7E-02 | 1.70 | 3.5E-02 | 1.60 | 1.3E-02 | 1.64 |
| rs7577157 | A(0.111) | 7.3E-03 | 1.29 | 3.5E-02 | 1.48 | 8.4E-04 | 1.33 | 6.0E-01 | 1.14 | 4.7E-02 | 1.70 | 3.5E-02 | 1.60 | 1.3E-02 | 1.64 |
*For each analysis, N size is reported in brackets (cases/controls).
†MA(F)=minor tested allele and its frequency (F); significant p values in bold type.
GWAS, genome-wide association study.