Table 3

Risk factors for CRC in 434 patients with SPS

Patients with CRC (n=127)Patients without CRC (n=307)Univariate OR (95% CI)p ValueMultivariable OR (95% CI)p Value
Age at diagnosis SPS in years; median (IQR)63.6 (58.1–69.6)59.4 (48.2–65.4)1.04 (1.02 to 1.06)<0.0011.03 (1.01 to 1.05)<0.001
Male gender; n (%)55 (43.3)156 (50.8)0.74 (0.49 to 1.12)0.16
A history of smoking; n (%)*43 (44.3)139 (62.3)0.48 (0.30 to 0.78)<0.010.36 (0.23 to 0.56)<0.001
BMI ≥30; n (%)*9 (10.6)32 (19.0)0.50 (0.22 to 1.07)0.09
At least one FDR with CRC; n (%)*38 (34.2)111 (40.1)0.78 (0.49 to 1.23)0.29
At least one FDR with SPS; n (%)5 (4.1)20 (6.7)0.60 (0.20 to 1.51)0.31
No. of SPs; median (IQR)29 (18–46)29 (17–52)1.00 (0.99 to 1.01)0.67
No. of SPs ≥10 mm; median (IQR)3 (1–5)3 (1–5)0.99 (0.96 to 1.03)0.69
No. of SPs proximal to the rectosigmoid; median (IQR)†15 (8–27)13 (7–25)1.00 (0.99 to 1.01)0.94
No. of SPs ≥10 mm proximal to the rectosigmoid; median (IQR)†3 (1–5)2 (1–4)1.00 (0.96 to 1.04)0.99
At least 1 SP containing dysplasia; n (%)48 (37.8)66 (21.5)2.34 (1.48 to 3.70)<0.0012.07 (1.28 to 3.33)<0.01
No. of adenomas; median (IQR)2 (1–5)2 (0–5)1.03 (0.98 to 1.08)0.30
At least 1 advanced adenoma; n (%)64 (50.4)89 (29.0)2.46 (1.59 to 3.80)<0.0012.30 (1.47 to 3.67)<0.001
Fulfilling WHO criteria 1 and 3; n (%)50 (39.4)88 (28.7)1.62 (1.05 to 2.49)0.021.60 (1.04 to 2.51)<0.05
  • *Referred to patients in which the variable was available.

  • †Proximal is defined as proximal to the rectosigmoid.

  • BMI, body mass index; CRC, colorectal cancer; FDR, first-degree relative; SPs, serrated polyps; SPS, serrated polyposis syndrome.