Organ/system | Variable | Score=1 | Score=2 | Score=3 |
---|---|---|---|---|
Liver | Bilirubin (mg/dL) | <6 | 6 to ≤12 | >12 |
Kidney | Creatinine (mg/dL) | <2 | 2 to <3.5 | ≥3.5 or RRT |
Brain | Encephalopathy grade (West-Haven) | 0 | 1–2 | 3–4 |
Coagulation | INR | <2 | 2 to <2.5 | ≥2.5 |
Circulation | MAP (mm Hg) | ≥70 | <70 | Vasopressors |
Respiratory | PaO2/FiO2 or SpO2/FiO2 | >300 >357 | ≤300 and >200 >214 and ≤357 | ≤200 ≤214 |
Highlighted areas indicate the definition of each organ failure.
CLIF, chronic liver failure; FiO2, fraction of inspired oxygen; INR, international normalised ratio; MAP, mean arterial pressure; PaO2, partial pressure of arterial oxygen; RRT, renal replacement therapy; SOFA, Sequential Organ Failure Assessment; SpO2, pulse oxymetric saturation.