Calculated cumulative incidences for any cancer from 25, 40, 50 and 60 years of age (current age) to 70 years of age for Lynch syndrome (LS) patients by mutated gene, in LS patients without cancer at current age in LS patients without prior or prevalent cancer at first colonoscopy
| Current age | Cumulative incidence for any first cancer from current age to 70 years by mutated gene (95% CI) | |||
|---|---|---|---|---|
| MLH1 | MSH2 | MSH6 | PMS2 | |
| 25 | 72% (64.7 to 78.7) | 72% (61.9 to 81.2) | 54% (38.6 to 68.6) | 18% (0.0 to 41.0) |
| 40 | 66% (57.8 to 74.2) | 67% (55.8 to 77.8) | 53% (38.6 to 68.6) | 18% (0.0 to 41.0) |
| 50 | 53% (41.9 to 63.6) | 55% (40.4 to 69.0) | 43% (26.4 to 60.2) | 18% (0.0 to 41.0) |
| 60 | 32% (17.7 to 45.4) | 33% (14.4 to 51.5) | 24% (5.6 to 42.2) | 0% (–) |