Table 2

Examples of available definitions of organ failures used in patients with cirrhosis

Failing organAsian Pacific Association for the Study of the Liver organ failures definition (4, 5)European Association for the Study of Liver-Chronic Liver failure organ failures definition (9)North American Consortium for Study of End-stage Liver Disease organ failures definition (7)
LiverTotal bilirubin ≥5 mg/dL and INR ≥1.5Bilirubin level of >12 mg/dL
KidneyAcute Kidney Injury Network criteriaCreatinine level of ≥2.0 mg/dL or renal replacementNeed for dialysis or other forms of renal replacement therapy
BrainWest-Haven hepatic encephalopathy grade 3–4West-Haven hepatic encephalopathy grade 3–4West-Haven hepatic encephalopathy grade 3–4
CoagulationINR ≥1.5INR ≥2.5
CirculationUse of vasopressor (terlipressin and/or catecholamines)Presence of shock defined by mean arterial pressure <60 mm Hg or a reduction of 40 mm Hg in systolic blood pressure from baseline, despite adequate fluid resuscitation and cardiac output
RespirationPaO2/FiO2 of ≤200 or SpO2/FiO2 of ≤214 or need for mechanical ventilationNeed for mechanical ventilation
  • FiO2, fraction of inspired oxygen; INR, international normalised ratio; PaO2, partial pressure of arterial oxygen; SpO2, pulse oximetric saturation.