Table 1

Association of IL-17 lymphocyte count and clinicopathological features in CRC (n=1148)

Clinicopathological featuresIL-17* lymphocyte countp Value
Median/meanMin–max
All3/13.80–350
Tumour location
 Right-sided3/12.60–2000.94†
 Left-sided3/14.30–3320.13‡
 Rectum4/13.70–350
MMR status
 Proficient3/13.60–3500.18
 Deficient4/14.50–167
pT stage
 pT1–25.5/15.10–1500.03
 pT3–43/13.70–350
pN stage
 pN04/15.50–3500.03
 pN1–23/12.30–350
Tumour grade
 G1–24/14.20–3500.01
 G32/12.10–200
Vascular invasion
 Absent4/15.10–3500.03
 Present3/10.70–250
Tumour border
 Pushing4/12.30–2500.78
 Infiltrating3/14.90–350
Peritumoral lymphocytic inflammation
 Absent3/13.40–350<0.001
 Present7.5/15.80–250
Local recurrence
 Absent1/8.50–3500.35
 Present1/6.10–200
Distant metastasis
 Absent1/8.20–3500.10
 Present1/3.80–30
Death
 Censured3/14.10–3500.5
 Present4/13.80–332
  • p Value calculated according to the Mann–Whitney test. Significant p values are shown in bold.

  • *As assessed by staining I (see ‘Materials and methods’).

  • †Right-sided versus left-sided.

  • ‡Right-sided or left-sided versus rectum.

  • CRC, colorectal cancers; IL, interleukin; MMR, mismatch repair.