Association of single-nucleotide polymorphisms (SNPs) at the TERT gene region with leucocyte telomere length in five prospective cohorts
| SNP | Major allele | Minor allele | Subjects | β-Value* | SE | p Value |
|---|---|---|---|---|---|---|
| rs401681 | G | A | 1208 | −0.09 | 0.04 | 0.023 |
| rs2736100 | C | A | 1208 | −0.04 | 0.04 | 0.394 |
| rs2736098 | C | T | 522 | 0.05 | 0.08 | 0.519 |
*Linear regression model per SNP minor allele adjusted for age (continuous), case–control status, prospective cohort (HPFS, NHS, PHS, WHI-OS, WHS, also adjusts for sex), smoking status (never, past, current), history of diabetes mellitus (yes, no), body mass index (<18.5, 18.5–24.9, 25–29.9, ≥30 kg/m2) and physical activity (quartiles) using an additive genetic model.
HPFS, Health Professionals Follow-up Study; NHS, Nurses’ Health Study; PHS, Physicians’ Health Study I; TERT, telomerase reverse transcriptase; WHI-OS, Women's Health Initiative Observational Study; WHS, Women's Health Study.