Table 5

Association of single-nucleotide polymorphisms (SNPs) at the TERT gene region with leucocyte telomere length in five prospective cohorts

SNPMajor alleleMinor alleleSubjectsβ-Value*SEp Value
rs2736098CT 5220.050.080.519
  • *Linear regression model per SNP minor allele adjusted for age (continuous), case–control status, prospective cohort (HPFS, NHS, PHS, WHI-OS, WHS, also adjusts for sex), smoking status (never, past, current), history of diabetes mellitus (yes, no), body mass index (<18.5, 18.5–24.9, 25–29.9, ≥30 kg/m2) and physical activity (quartiles) using an additive genetic model.

  • HPFS, Health Professionals Follow-up Study; NHS, Nurses’ Health Study; PHS, Physicians’ Health Study I; TERT, telomerase reverse transcriptase; WHI-OS, Women's Health Initiative Observational Study; WHS, Women's Health Study.