Table 2

Association between prediagnostic leucocyte telomere length and future risk of pancreatic cancer

Quintiles of leucocyte telomere length, z score
Q5 (longest)Q4Q3Q2Q1 (shortest)p Value, trend*
No. of cases6484727195
No. of controls179180179178180
OR (95% CI)†1.01.35 (0.90–2.04)1.23 (0.79–1.93)1.27 (0.79–2.02)1.72 (1.07–2.78)0.048
OR (95% CI)‡1.01.29 (0.85–1.96)1.20 (0.76–1.89)1.27 (0.80–2.04)1.67 (1.03–2.72)0.056
  • *p Value for trend calculated by the Wald test of a score variable containing median values of quintiles.

  • †Conditional logistic regression model conditioned on matching factors: year of birth, prospective cohort (HPFS, NHS, PHS, WHI-OS, WHS, which also matches on sex), smoking status (never, past, current), fasting status at blood collection (<8 hours, ≥8 hours) and month/year of blood collection.

  • ‡Conditional logistic regression model conditioned on matching factors and adjusted for history of diabetes mellitus (yes, no), body mass index (<18.5, 18.5–24.9, 25–29.9, ≥30 kg/m2) and physical activity (quartiles).

  • HPFS, Health Professionals Follow-up Study; NHS, Nurses’ Health Study; PHS, Physicians’ Health Study I; WHI-OS, Women's Health Initiative Observational Study; WHS, Women's Health Study.