The sensitivities and specificities of faecal immunochemical test (FIT), and the combined FIT and marker Fusobacterium nucleatum (Fn) test, for colorectal cancer and advanced adenoma
| FIT | FIT+Fn | Comparison | |||||
|---|---|---|---|---|---|---|---|
| Findings | No. | Sensitivity (%) | Specificity (%) | No. | Sensitivity (%) | Specificity (%) | p Value |
| Colorectal cancer (n=104) | 76 | 73.1 (64.4–81.8) | 98.0 (95.1–100) | 96 | 92.3 (86.5–97.1) | 93.0 (88.0–97.0) | <0.001 |
| TNM stage | |||||||
| Stage 1 (n=22) | 15 | 68.2 (50.0–86.4) | Same as above | 19 | 86.4 (72.7–100.0) | Same as above | |
| Stage 2 (n=31) | 23 | 74.2 (58.1–90.3) | 29 | 93.6 (83.9–100.0) | |||
| Stage 3 (n=39) | 30 | 76.9 (64.1–89.7) | 37 | 94.9 (87.2–100.0) | |||
| Stage 4 (n=12) | 8 | 66.7 (41.7–91.7) | 11 | 91.7 (75.0–100.0) | |||
| Location | |||||||
| Proximal (n=28) | 23 | 82.1 (67.9–96.4) | Same as above | 26 | 92.9 (82.1–100.0) | Same as above | |
| Distal (n=76) | 53 | 69.7 (59.2–80.3) | 70 | 92.1 (85.5–97.4) | |||
| Advanced adenoma (n=103) | 16 | 15.5 (8.7–22.3) | 98.0 (95.1–100) | 39 | 38.6 (28.7–48.5) | 89.0 (83.0–95.0) | 0.007 |
Test performance was compared using the one-sided Delong's test to test for incremental gain in area under the receiver-operating characteristic curve (AUC).