Univariate | Multivariate* | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Quartile of DNA methylation level | Quartile of DNA methylation level | |||||||||
Variable | Q1 (lowest) | Q2 | Q3 | Q4 (highest) | p for trend | Q1 (lowest) | Q2 | Q3 | Q4 (highest) | p for trend |
No of patients (795) | ||||||||||
miR-124a-3 | 198 | 199 | 199 | 199 | 198 | 199 | 199 | 199 | ||
EMX1 | 198 | 199 | 199 | 199 | 198 | 199 | 199 | 199 | ||
NKX6-1 | 198 | 199 | 199 | 199 | 198 | 199 | 199 | 199 | ||
All metachronous gastric cancers | ||||||||||
miR-124a-3 | ||||||||||
No of events | 18 | 33 | 32 | 50 | 18 | 33 | 32 | 50 | ||
HR (95% CI) | 1 | 1.73 (0.97 to 3.08) | 1.64 (0.91 to 2.94) | 2.89 (1.66 to 5.02) | 0.0002 | 1 | 1.64 (0.90 to 2.99) | 1.48 (0.80 to 2.74) | 2.57 (1.43 to 4.61) | 0.002 |
EMX1 | ||||||||||
No of events | 18 | 28 | 40 | 47 | 18 | 28 | 40 | 47 | ||
HR (95% CI) | 1 | 1.47 (0.81 to 2.67) | 2.09 (1.19 to 3.67) | 2.63 (1.51 to 4.56) | 0.0001 | 1 | 1.46 (0.79 to 2.68) | 1.75 (0.98 to 3.13) | 2.33 (1.31 to 4.15) | 0.0027 |
NKX6-1 | ||||||||||
No of events | 21 | 24 | 37 | 51 | 21 | 24 | 37 | 51 | ||
HR (95% CI) | 1 | 1.13 (0.63 to 2.05) | 1.65 (0.95 to 2.85) | 2.42 (1.42 to 4.10) | 0.0002 | 1 | 1.12 (0.61 to 2.06) | 1.61 (0.91 to 2.84) | 2.26 (1.30 to 3.92) | 0.0008 |
Authentic metachronous gastric cancers | ||||||||||
miR-124a-3 | ||||||||||
No of events | 14 | 30 | 26 | 46 | 14 | 30 | 26 | 46 | ||
HR (95% CI) | 1 | 2.03 (1.07 to 3.85) | 1.73 (0.89 to 3.33) | 3.53 (1.91 to 6.53) | <0.0001 | 1 | 1.93 (1.00 to 3.75) | 1.50 (0.75 to 2.97) | 3.00 (1.58 to 5.72) | 0.0017 |
EMX1 | ||||||||||
No of events | 15 | 24 | 35 | 42 | 15 | 24 | 35 | 42 | ||
HR (95% CI) | 1 | 1.52 (0.79 to 2.90) | 2.21 (1.20 to 4.07) | 2.87 (1.58 to 5.23) | 0.0001 | 1 | 1.44 (0.74 to 2.81) | 1.79 (0.95 to 3.38) | 2.45 (1.31 to 4.58) | 0.0028 |
NKX6-1 | ||||||||||
No of events | 17 | 18 | 33 | 48 | 17 | 18 | 33 | 48 | ||
HR (95% CI) | 1 | 1.07 (0.55 to 2.09) | 1.86 (1.02 to 3.89) | 2.92 (1.64 to 5.20) | <0.0001 | 1 | 1.03 (0.52 to 2.04) | 1.74 (0.93 to 3.24) | 2.63 (1.44 to 4.82) | 0.0001 |
*Adjusted for hospital, gender and age (<50, 50–59, 60–69 or ≥70), pepsinogen index, history of endoscopic submucosal dissection (0, 1, 2 or 3 times), pack-years of smoking (0, 1–39 or ≥40) and green vegetable intake (≤2 days/week, 3–4 days/week or almost daily).