Categories | Functions annotation | FDR | Predicted activation state | Activation z-score | Number of genes |
---|---|---|---|---|---|
Cell death and survival | Cell death of epithelial cells | 2.20E-08 | ns | 0.667 | 56 |
Apoptosis of epithelial cells | 1.87E-06 | ns | 0.511 | 34 | |
Neuronal cell death | 7.94E-06 | ns | 0.872 | 63 | |
Cell death of epithelial cell lines | 4.96E-05 | ns | 0.285 | 29 | |
Anoikis | 6.52E-04 | ns | 0.701 | 12 | |
Cell death of blood cells | 1.57E-03 | ns | 0.76 | 54 | |
Cellular assembly and organisation | Reorganisation of cytoskeleton | 8.00E-04 | ns | 1.166 | 71 |
Formation of cytoskeleton | 1.23E-03 | ns | 1.37 | 36 | |
Organisation of cytoskeleton | 5.57E-03 | Increased | 2.47 | 93 | |
Outgrowth of neurites | 1.46E-04 | Increased | 3.25 | 38 | |
Cell development | Differentiation of epithelial cells | 4.30E-04 | ns | 1.89 | 27 |
Differentiation of epithelial tissue | 5.04E-04 | Increased | 2.001 | 30 | |
Proliferation of neuronal cells | 7.58E-04 | Increased | 3.181 | 47 | |
Differentiation of blood cells | 8.08E-04 | Increased | 2.385 | 58 | |
Proliferation of blood cells | 8.41E-04 | ns | −0.184 | 64 | |
Proliferation of immune cells | 1.83E-03 | ns | −0.065 | 59 | |
Epithelial-mesenchymal transition | 1.84E-03 | ns | 1.505 | 17 | |
Cell-to-cell signalling and interaction | Architecture of junctional complexes | 4.90E-04 | ns | 1.224 | 4 |
Disorganisation of tight junctions | 1.42E-03 | ns | ns | 6 | |
Degradation of intercellular junctions | 1.67E-03 | ns | ns | 8 | |
Formation of tight junctions | 5.20E-03 | ns | −0.954 | 8 | |
Function of tight junctions | 6.00E-03 | ns | 0.816 | 6 | |
Humoral immune response | Quantity of immunoglobulin | 1.82E-03 | ns | −0.269 | 16 |
Quantity of B lymphocytes | 3.72E-03 | ns | 0.991 | 17 | |
Quantity of IgG1 | 2.57E-03 | ns | 0.308 | 9 | |
Quantity of IgM | 9.85E-03 | ns | −0.57 | 8 |
Activation z-score indicates probability score of the activation states of molecular functions to determine ‘activated’ (z>0) or ‘inhibited’ predictions (z<0); z-scores greater than 2 or smaller than −2 can be considered significant. p Values are adjusted for multiple testing by the Benjamini and Hochberg method.
FDR, false discovery rate; mRNA, messenger RNA; miRNA, micro-RNA; ns, not significant.