Baseline characteristics of patients who are morbidly obese with NAFL and NASH
| NAFL (n=340) | NASH (n=279) | p Value (NAFL vs NASH) | |
|---|---|---|---|
| Demographic | |||
| Age at surgery (year) | 42.9 (41.7 to 44.1) | 46.3 (44.9 to 47.6) | <0.001 |
| Age at onset of obesity (year) | 20.0 (18.3 to 21.6) | 20.8 (18.8 to 22.8) | ns |
| Duration of obesity (year) | 22.9 (21.6 to 24.2) | 26.2 (24.5 to 27.9) | <0.001 |
| Female gender | 271 (80%) | 184 (66%) | <0.001 |
| Caucasian | 237 (78%) | 212 (84%) | ns |
| Clinical | |||
| Hypertension | 157 (48%) | 161 (59%) | <0.01 |
| Type 2 diabetes mellitus | 104 (37%) | 145 (60%) | <0.0001 |
| Dyslipidemia | 165 (50%) | 169 (61%) | <0.01 |
| Obstructive sleep apnoea | 114 (34%) | 121 (43%) | <0.01 |
| Anthropometric | |||
| BMI (kg/m2) | 48.0 (47.3 to 48.8) | 47.8 (46.9 to 48.7) | ns |
| Weight (kg) | 131.9 (129.3 to 134.6) | 134.4 (131.3 to 137.5) | ns |
| Waist circumference (cm) | 165.5 (164.5 to 166.4) | 167.4 (166.2 to 168.5) | <0.05 |
| Body fat mass (%) | 49.1 (48.6 to 49.7) | 47.4 (46.8 to 48.0) | <0.0001 |
| Trunk/limb fat mass | 1.21 (1.17 to 1.24) | 1.34 (1.31 to 1.39) | <0.0001 |
| Liver function tests | |||
| ALT (IU/L) | 34.3 (31.5 to 37.1) | 45.1 (41.1 to 49.1) | <0.0001 |
| AST (IU/L) | 27.7 (26.3 to 29.2) | 34.7 (32.8 to 36.6) | <0.0001 |
| GGT (IU/L) | 49.1 (35.7 to 62.5) | 59.8 (53.7 to 66.0) | ns |
| Laboratory parameters | |||
| Fasting glucose (mmol/L) | 6.1 (5.9 to 6.4) | 6.9 (6.6 to 7.3) | <0.0001 |
| Haemoglobin A1C (%) | 6.4 (6.2 to 6.5) | 6.8 (6.7 to 7.0) | <0.0001 |
| Fasting insulin (µU/mL) | 22.1 (18.2 to 26.1) | 28.7 (23.4 to 34.0) | <0.05 |
| Total cholesterol (mmol/L) | 4.9 (4.8 to 5.0) | 4.7 (4.6 to 4.8) | <0.01 |
| HDL cholesterol (mmol/L) | 1.2 (1.1 to 1.2) | 1.1 (1.0 to 1.1) | <0.001 |
| Triglycerides (mmol/L) | 1.6 (1.5 to 1.8) | 1.8 (1.7 to 1.9) | ns |
Data are given as mean (95% CI) or n (%).
ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; GGT, γ-glutamyl transpeptidase; HDL, high-density lipoprotein; IU, international unit; NAFL, non-alcoholic fatty liver; NASH, non-alcoholic steatohepatitis; ns, not significant; Y, year.