Table 2

Canonical signalling pathways associated with IBS-D gene expression profile

Ingenuity canonical signalling pathwaysFDRRatio*
PTEN signalling0.000050.35
Axonal guidance signalling0.00020.25
PI3K/AKT signalling0.00050.32
ERK/MAPK signalling0.00060.29
B-cell receptor signalling0.0020.28
Tight junction signalling0.0080.27
Caveolar-mediated endocytosis signalling0.020.31
Actin cytoskeleton signalling0.040.24
Epithelial adherens junction signalling0.040.25
NF-κB signalling0.040.24
p38 MAPK signalling0.050.26
Regulation of actin-based motility by rho0.080.26
Role of NFAT in regulation of the immune response0.100.23
Antigen presentation pathway0.380.24
  • *Ratio: number of genes in the analysis that are associated with the canonical pathway divided by the total number of genes that map to the canonical pathway.

  • PTEN, phosphatase and tensin homologue deleted on chromosome ten; PI3K/AKT, phosphoinositide-3-kinase/v-akt murine thymoma viral oncogene homologue 1; ERK/MAPK, extracellular signal-regulated kinase/mitogen-activated protein kinase; NF-κB, nuclear factor κB; NFAT, nuclear factor of activated T cells; FDR, false discovery rate, p values are adjusted for multiple testing by the Benjamini and Hochberg method.