Canonical signalling pathways associated with IBS-D gene expression profile
| Ingenuity canonical signalling pathways | FDR | Ratio* |
|---|---|---|
| PTEN signalling | 0.00005 | 0.35 |
| Axonal guidance signalling | 0.0002 | 0.25 |
| PI3K/AKT signalling | 0.0005 | 0.32 |
| ERK/MAPK signalling | 0.0006 | 0.29 |
| B-cell receptor signalling | 0.002 | 0.28 |
| Tight junction signalling | 0.008 | 0.27 |
| Caveolar-mediated endocytosis signalling | 0.02 | 0.31 |
| Actin cytoskeleton signalling | 0.04 | 0.24 |
| Epithelial adherens junction signalling | 0.04 | 0.25 |
| NF-κB signalling | 0.04 | 0.24 |
| p38 MAPK signalling | 0.05 | 0.26 |
| Regulation of actin-based motility by rho | 0.08 | 0.26 |
| Role of NFAT in regulation of the immune response | 0.10 | 0.23 |
| Antigen presentation pathway | 0.38 | 0.24 |
*Ratio: number of genes in the analysis that are associated with the canonical pathway divided by the total number of genes that map to the canonical pathway.
PTEN, phosphatase and tensin homologue deleted on chromosome ten; PI3K/AKT, phosphoinositide-3-kinase/v-akt murine thymoma viral oncogene homologue 1; ERK/MAPK, extracellular signal-regulated kinase/mitogen-activated protein kinase; NF-κB, nuclear factor κB; NFAT, nuclear factor of activated T cells; FDR, false discovery rate, p values are adjusted for multiple testing by the Benjamini and Hochberg method.