TableĀ 2

Statistical analysis of pancreatic juice mutation concentrations by digital NGS scores

KRAS onlyGNAS onlyTP53 onlyTP53+SMAD4All 9 genes
dNGS #nMeanSDMeanSDMeanSDMeanSDMeanSD
Controls240.81.40.41.00.00.00.00.01.31.8
IPMN563.96.91.11.80.71.20.81.37.18.9
PDAC348.2132.410.46.516.38.216.620.729.6
KRAS onlyGNAS onlyTP53 onlyTP53+SMAD4All 9 genes
Mann-Whitney testp Valuep Valuep Valuep Valuep Value
PDAC vs controls0.0010.098<0.0001<0.0001<0.0001
IPMN v controls<0.0010.0060.0070.007<0.0001
PDAC vs IPMN0.3350.2810.0003<0.00010.003
  • dNGS#, digital NGS score (mutation concentration); IPMN, intraductal papillary mucinous neoplasm; NGS, next-generation sequencing; PDAC, pancreatic ductal adenocarcinoma.