Table 2

Statistical analysis of pancreatic juice mutation concentrations by digital NGS scores

		KRAS only		GNAS only		TP53 only		TP53+SMAD4		All 9 genes
dNGS #	n	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD
Controls	24	0.8	1.4	0.4	1.0	0.0	0.0	0.0	0.0	1.3	1.8
IPMN	56	3.9	6.9	1.1	1.8	0.7	1.2	0.8	1.3	7.1	8.9
PDAC	34	8.2	13	2.4	10.4	6.5	16.3	8.2	16.6	20.7	29.6
		KRAS only		GNAS only		TP53 only		TP53+SMAD4		All 9 genes
Mann-Whitney test		p Value		p Value		p Value		p Value		p Value
PDAC vs controls		0.001		0.098		<0.0001		<0.0001		<0.0001
IPMN v controls		<0.001		0.006		0.007		0.007		<0.0001
PDAC vs IPMN		0.335		0.281		0.0003		<0.0001		0.003

dNGS#, digital NGS score (mutation concentration); IPMN, intraductal papillary mucinous neoplasm; NGS, next-generation sequencing; PDAC, pancreatic ductal adenocarcinoma.