Upstream regulators associated with mRNA targets
| Upstream regulator | Predicted activation state | Activation z-score | p Value of overlap | Target molecules in dataset |
|---|---|---|---|---|
| hsa-miR-125b-5p | Inhibited | −11.514 | 2.98E-129 | 204 (231) |
| hsa-miR-16-5p | Inhibited | −4.849 | 1.4E-22 | 94 (128) |
| hsa-miR-29b-3p | Inhibited | −6.892 | 2.5E-20 | 88 (105) |
| hsa-let-7a-5p | Inhibited | −5.549 | 3.89E-19 | 82 (106) |
| hsa-miR-128-3p | Inhibited | −3.192 | 1.71E-18 | 66 (98) |
| hsa-miR-24-3p | Inhibited | −6.702 | 9.78E-18 | 69 (77) |
| hsa-miR-103-3p | Inhibited | −2.512 | 8.50E-17 | 51 (75) |
| hsa-miR-92a-3p | −1.791 | 5.39E-09 | ||
| hsa-miR-155-5p | Inhibited | −2.17 | 5.75E-08 | 31 (47) |
| hsa-miR-338-3p | Inhibited | −2.108 | 1.32E-04 | 20 (29) |
Activation z-score: probability score of the activation states of predicted transcriptional regulators to determine ‘activated’ (z>0) or ‘inhibited’ predictions (z<0); z-scores greater than 2 or smaller than –2 are considered significant. p Value of overlap: overlap between the dataset mRNAs and the mRNAs regulated by the respective upstream regulator calculated by Fisher's exact test, p values <0.01 are considered significant; target molecules in dataset: number of mRNAs that show an expression direction consistent with the predicted activation state of the respective upstream regulator (total number of target mRNAs for the respective upstream regulator).
mRNA, messenger RNA; miRNA, micro-RNA.