PPVs and detection rates by sex, with different FIT cut-off concentrations (µg Hb/g faeces)
| FIT 20 μg | 40 μg | 100 μg | 150 μg | 180 μg | gFOBt | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Male | Female | All | Male | Female | All | Male | Female | All | Male | Female | All | Male | Female | All | Male | Female | All | |
| Adequately participated | 12 813 | 14 354 | 27 167 | 12 813 | 14 354 | 27 167 | 12 813 | 14 354 | 27 167 | 12 813 | 14 354 | 27 167 | 12 813 | 14 354 | 27 167 | 309 596 | 358 349 | 667 945 |
| Positive screening | 1183 | 944 | 2127 | 832 | 584 | 1416 | 397 | 259 | 656 | 300 | 183 | 483 | 258 | 154 | 412 | 6529 | 5046 | 11 575 |
| Positivity | 9.23% | 6.58% | 7.83% | 6.49% | 4.07% | 5.21% | 3.10% | 1.80% | 2.41% | 2.34% | 1.27% | 1.78% | 2.01% | 1.07% | 1.52% | 2.11% | 1.41% | 1.73% |
| Attended diagnostic test | 998 | 826 | 1824 | 695 | 507 | 1202 | 320 | 226 | 546 | 241 | 159 | 400 | 206 | 133 | 339 | 5566 | 4269 | 9835 |
| Uptake of diagnostic tests | 84.36% | 87.50% | 85.75% | 83.53% | 86.82% | 84.95% | 80.60% | 87.26% | 83.23% | 80.33% | 86.89% | 82.82% | 79.84% | 86.36% | 82.28% | 85.25% | 84.60% | 84.97% |
| Cancer | 50 | 23 | 73 | 45 | 20 | 65 | 31 | 13 | 44 | 29 | 11 | 40 | 26 | 10 | 36 | 517 | 301 | 818 |
| Cancer detection rate | 0.39% | 0.16% | 0.27% | 0.35% | 0.14% | 0.24% | 0.24% | 0.09% | 0.16% | 0.23% | 0.08% | 0.15% | 0.20% | 0.07% | 0.13% | 0.17% | 0.08% | 0.12% |
| Advanced adenoma | 307 | 164 | 471 | 237 | 114 | 351 | 125 | 58 | 183 | 91 | 42 | 133 | 80 | 36 | 116 | 1605 | 759 | 2364 |
| Advanced adenoma detection rate | 2.40% | 1.14% | 1.73% | 1.85% | 0.79% | 1.29% | 0.98% | 0.40% | 0.67% | 0.71% | 0.29% | 0.49% | 0.62% | 0.25% | 0.43% | 0.52% | 0.21% | 0.35% |
| Cancer PPV | 5.01% | 2.78% | 4.00% | 6.47% | 3.94% | 5.41% | 9.69% | 5.75% | 8.06% | 12.03% | 6.92% | 10.00% | 12.62% | 7.52% | 10.62% | 9.29% | 7.05% | 8.32% |
| Advanced adenoma PPV | 30.76% | 19.85% | 25.82% | 34.10% | 22.49% | 29.20% | 39.06% | 25.66% | 33.52% | 37.76% | 26.42% | 33.25% | 38.83% | 27.07% | 34.22% | 28.84% | 17.78% | 24.04% |
| ORs (FIT vs gFOBt) (95% CI) | All | All | All | All | All | All | ||||||||||||
| Cancer detection | 2.20 (1.73 to 2.79) | 1.96 (1.52 to 2.52) | 1.32 (0.98 to 1.79) | 1.20 (0.88 to 1.65) | 1.08 (0.77 to 1.51) | 1.0 | ||||||||||||
| Advanced adenoma detection | 4.97 (4.50 to 5.49) | 3.69 (3.29 to 4.13) | 1.91 (1.64 to 2.22) | 1.39 (1.16 to 1.65) | 1.21 (1.00 to 1.46) | 1.0 | ||||||||||||
| All neoplasm (cancer+advanced adenoma) detection | 4.27 (3.89 to 4.68) | 3.25 (2.93 to 3.60) | 1.76 (1.54 to 2.02) | 1.34 (1.15 to 1.46) | 1.18 (1.00 to 1.38) | 1.0 | ||||||||||||
| Cancer PPV | 0.47 (0.37 to 0.60) | 0.63 (0.49 to 0.82) | 0.94 (0.69 to 1.29) | 1.13 (0.81 to 1.57) | 1.26 (0.89 to 1.78) | 1.0 | ||||||||||||
| Advanced adenoma PPV | 1.10 (0.98 to 1.23) | 1.28 (1.13 to 1.46) | 1.50 (1.26 to 1.79) | 1.39 (1.14 to 1.71) | 1.52 (1.22 to 1.89) | 1.0 | ||||||||||||
| All neoplasm (cancer+advanced adenoma) PPV | 0.91 (0.82 to 1.01) | 1.09 (0.97 to 1.24) | 1.39 (1.18 to 1.64) | 1.47 (1.22 to 1.77) | 1.54 (1.25 to 1.88) | 1.0 | ||||||||||||
FIT, faecal immunochemical test; gFOBt, guaiac-based faecal occult blood test; Hb, haemoglobin; PPV, positive predictive value.