Table 3

Receiver operating characteristic (ROC) curve analysis of pancreatic juice mutation concentrations (overall 115#)

		KRAS only	GNAS only	TP53 only	TP53+SMAD4	All 9 genes
PDAC vs controls	AUC	0.74	0.61	0.79	0.82	0.89
	95% CI of AUC	0.62 to 0.87	0.46 to 0.76	0.68 to 0.91	0.72 to 0.93	0.80 to 0.97
	Specificity	91.7%	83.4%	100.0%	100.0%	83.4%
	Sensitivity	50.0%	38.2%	58.8%	64.7%	85.3%
	p Value	0.002	0.174	0.0002	<0.0001	<0.0001
IPMN vs controls	AUC	0.74	0.67	0.63	0.63	0.85
	95% CI of AUC	0.62 to 0.85	0.55 to 0.80	0.51 to 0.76	0.51 to 0.76	0.76 to 0.93
	Specificity	83.4%	83.4%	100.0%	100.0%	83.4%
	Sensitivity	57.1%	51.8%	26.8%	26.8%	73.2%
	p Value	0.001	0.015	0.058	0.058	<0.0001
PDAC vs IPMN	AUC	0.56	0.56	0.69	0.73	0.69
	95% CI of AUC	0.43 to 0.70	0.43 to 0.68	0.58 to 0.81	0.62 to 0.85	0.56 to 0.81
	Specificity	42.9%	51.8%	73.2%	73.2%	85.7%
	Sensitivity	52.9%	61.8%	58.8%	64.7%	52.9%
	p Value	0.290	0.324	0.002	0.0002	0.003

AUC, area under the curve; IPMN, intraductal papillary mucinous neoplasm; PDAC, pancreatic ductal adenocarcinoma.