Association between RNF43 truncating mutation and BRAF V600E mutation in MSI and MSS CRCs, and sporadic serrated adenomas in various study cohorts
| BRAF | ||||
|---|---|---|---|---|
| Wild type | V600E | Mutant % | p Value* | |
| HK MSI CRC (n=47) | ||||
| RNF43 wild type | 20 | 1 | 4.8 | 0.003 |
| RNF43 mutated | 15 | 11 | 42.3 | |
| TCGA MSI CRC (n=57) | ||||
| RNF43 wild type | 16 | 4 | 20.0 | <0.001 |
| RNF43 mutated | 11 | 26 | 70.3 | |
| MSI MLH1me+ CRC (HK+TCGA n=59) | ||||
| RNF43 wild type | 7 | 5 | 41.7 | 0.042† |
| RNF43 mutated | 12 | 35 | 74.5 | |
| TCGA MSS CRC (n=391) | ||||
| RNF43 wild type | 372 | 9 | 2.4 | 0.002† |
| RNF43 mutated | 7 | 3 | 30.0 | |
| Giannakis MSS CRC (n=137) | ||||
| RNF43 wild type | 117 | 14 | 10.7 | 0.025† |
| RNF43 mutated | 3 | 3 | 50.0 | |
| HK sporadic SSA/TSA (n=47) | ||||
| RNF43 wild type | 13 | 18 | 58.1 | 0.112 |
| RNF43 mutated | 3 | 13 | 81.3 | |
*Derived from a χ2 test unless otherwise specified.
†Derived from Fisher's exact test.
CRC, colorectal cancer; MSI, microsatellite instability; MSS, microsatellite stable; SSA, sessile serrated adenoma; TSA, traditional serrated adenoma.