Table 4

Oral bacteria taxa* and risk of pancreatic cancer stratified by smoking, alcohol consumption and time interval between oral sample collection and diagnosis date in the combined CPS II and PLCO cohort

Cases/controls (N)OR†95% CI†p Value†
Ever smokers207/185
 A. Actinomycetemcomitans2.190.87 to 5.480.096
 P. Gingivalis1.380.89 to 2.160.15
 Leptotrichia0.860.76 to 0.970.014
 Alloprevotella1.160.93 to 1.450.19
Never smokers154/186
 A. Actinomycetemcomitans1.780.69 to 4.620.23
 P. Gingivalis1.751.06 to 2.900.029
 Leptotrichia0.850.73 to 1.010.059
 Alloprevotella1.180.87 to 1.620.29
Ever drinkers279/286
A. actinomycetemcomitans3.031.31 to 7.030.0097
P. gingivalis1.501.03 to 2.200.035
Leptotrichia0.820.73 to 0.92<0.001
Alloprevotella1.200.97 to 1.470.086
Never drinkers82/85
A. actinomycetemcomitans0.470.13 to 1.720.25
P. gingivalis1.700.80 to 3.620.17
Leptotrichia1.020.81 to 1.280.87
Alloprevotella1.290.81 to 2.040.28
Oral sample collected ≤2 years prior to cancer diagnosis85/97‡
A. actinomycetemcomitans2.980.71 to 12.430.13
P. gingivalis1.600.77 to 3.310.21
Leptotrichia0.920.76 to 1.120.42
Alloprevotella1.130.81 to 1.570.47
Oral sample collected >2 years prior to cancer diagnosis276/280‡
A. actinomycetemcomitans1.600.75 to 3.380.22
P. gingivalis1.531.05 to 2.240.027
Leptotrichia0.840.75 to 0.940.0027
Alloprevotella1.210.97 to 1.500.090
  • All p for interactions were >0.05 (4 taxa×alcohol, smoking, or time interval).

  • *Taxa in the models were mutually adjusted.

  • †Values of ORs, 95% CIs and p values from logistic regression models after controlling for the random effect of cohorts as well as other covariates (age, race, sex, BMI, smoking status, alcohol consumption status and history of diabetes).

  • ‡Controls were included in the stratum of their matched case; six controls were used more than once due to matched cases having different time interval.

  • A. actinomycetemcomitans, Aggregatibacter actinomycetemcomitans; BMI, body mass index; CPS, Cancer Prevention Study; P. gingivalis, Porphyromonas gingivalis; PLCO, Prostate, Lung, Colorectal and Ovarian Cancer.