Oral bacteria taxa* and risk of pancreatic cancer stratified by smoking, alcohol consumption and time interval between oral sample collection and diagnosis date in the combined CPS II and PLCO cohort
| Cases/controls (N) | OR† | 95% CI† | p Value† | |
|---|---|---|---|---|
| Ever smokers | 207/185 | |||
| A. Actinomycetemcomitans | 2.19 | 0.87 to 5.48 | 0.096 | |
| P. Gingivalis | 1.38 | 0.89 to 2.16 | 0.15 | |
| Leptotrichia | 0.86 | 0.76 to 0.97 | 0.014 | |
| Alloprevotella | 1.16 | 0.93 to 1.45 | 0.19 | |
| Never smokers | 154/186 | |||
| A. Actinomycetemcomitans | 1.78 | 0.69 to 4.62 | 0.23 | |
| P. Gingivalis | 1.75 | 1.06 to 2.90 | 0.029 | |
| Leptotrichia | 0.85 | 0.73 to 1.01 | 0.059 | |
| Alloprevotella | 1.18 | 0.87 to 1.62 | 0.29 | |
| Ever drinkers | 279/286 | |||
| A. actinomycetemcomitans | 3.03 | 1.31 to 7.03 | 0.0097 | |
| P. gingivalis | 1.50 | 1.03 to 2.20 | 0.035 | |
| Leptotrichia | 0.82 | 0.73 to 0.92 | <0.001 | |
| Alloprevotella | 1.20 | 0.97 to 1.47 | 0.086 | |
| Never drinkers | 82/85 | |||
| A. actinomycetemcomitans | 0.47 | 0.13 to 1.72 | 0.25 | |
| P. gingivalis | 1.70 | 0.80 to 3.62 | 0.17 | |
| Leptotrichia | 1.02 | 0.81 to 1.28 | 0.87 | |
| Alloprevotella | 1.29 | 0.81 to 2.04 | 0.28 | |
| Oral sample collected ≤2 years prior to cancer diagnosis | 85/97‡ | |||
| A. actinomycetemcomitans | 2.98 | 0.71 to 12.43 | 0.13 | |
| P. gingivalis | 1.60 | 0.77 to 3.31 | 0.21 | |
| Leptotrichia | 0.92 | 0.76 to 1.12 | 0.42 | |
| Alloprevotella | 1.13 | 0.81 to 1.57 | 0.47 | |
| Oral sample collected >2 years prior to cancer diagnosis | 276/280‡ | |||
| A. actinomycetemcomitans | 1.60 | 0.75 to 3.38 | 0.22 | |
| P. gingivalis | 1.53 | 1.05 to 2.24 | 0.027 | |
| Leptotrichia | 0.84 | 0.75 to 0.94 | 0.0027 | |
| Alloprevotella | 1.21 | 0.97 to 1.50 | 0.090 |
All p for interactions were >0.05 (4 taxa×alcohol, smoking, or time interval).
*Taxa in the models were mutually adjusted.
†Values of ORs, 95% CIs and p values from logistic regression models after controlling for the random effect of cohorts as well as other covariates (age, race, sex, BMI, smoking status, alcohol consumption status and history of diabetes).
‡Controls were included in the stratum of their matched case; six controls were used more than once due to matched cases having different time interval.
A. actinomycetemcomitans, Aggregatibacter actinomycetemcomitans; BMI, body mass index; CPS, Cancer Prevention Study; P. gingivalis, Porphyromonas gingivalis; PLCO, Prostate, Lung, Colorectal and Ovarian Cancer.