Table 2

Liver aetiology table for patients with non-acute abnormal liver blood tests

Standard liver aetiology panelExtended liver aetiology panel
Viral hepatitisHepatitis B surface antigen AND hepatitis C antibody (with follow-on PCR if positive)Anti-HBc and anti-HBs hepatitis B DNA quantification of hepatitis delta in high-prevalence areas
Iron overloadFerritin AND transferrin saturationHaemochromatosis gene testing
Autoimmune liver disease
(excluding PSC)
Anti-mitochondrial antibody, anti-smooth muscle antibody, antinuclear antibody, serum immunoglobulinsAnti-LKM antibody and coeliac antibodies
(consider ANCA in the presence of cholestatic liver blood tests)
Metabolic liver diseaseAlpha-1-antitrypsin level; thyroid function tests; caeruloplasmin (age >3 and <40 years)±urinary copper collection
  • ANCA, antineutrophil cytoplasmic antibodies; LKM, liver kidney miscrosome; PCR, polymerase chain reaction; PSC, primary sclerosing cholangitis.