The effect of having IBD on visceral afferent mechanosensitivity and chemosensitivity. Table illustrating single unit responses to VFH probing at 0.07, 0.4, and 2 g, bradykinin, or ATP in tissues from patients having surgical resections for cancer, and patients having resections for IBD
| Mechanosensitivity | ||||||
|---|---|---|---|---|---|---|
| Cancer | IBD | |||||
| Firing rate spikes 2 s−1 probe (proportion responders) | Firing rate spikes 2 s−1 probe (proportion responders) | |||||
| VFH (g) | 0.07 | 0.4 | 2 | 0.07 | 0.4 | 2 |
| All tissues | 8.8±1.8 (7/13) (54%) | 17.8±2.7 (12/13) (92%) | 23.7±3.3 (11/11) (100%) | 6.5±0.5 (2/2) (100%) | 11.0±0.0 (2/2) (100%) | 13.8±2.8 (2/2) (100%) |
| Sigmoid colon | 9.1±1.6 (4/8) (50%) | 20.6±3.7 (7/8) (88%) | 25.4±4.6 (7/7) (100%) | – | – | – |
| Rectum | 7.8±7.3 (2/3) (67%) | 15.7±5.2 (3/3) (100%) | 24.2±4.4 (3/3) (100%) | 7 (1/1) (100%) | 11 (1/1) (100%) | 11 (1/1) (100%) |
| Bradykinin | ||||
|---|---|---|---|---|
| Proportion responders | Δ Firing rate (spikes 20 s−1) | Proportion responders | Δ Firing rate (spikes 20 s−1) | |
| All tissues | 24/39 (62%) | 49.1±8.6NS | 7/10 (70%) | 23.5±6.9NS |
| Sigmoid colon | 12/23 (52%) | 57.7±14.7 | 1/1 (100%) | 52.5 |
| Rectum | 5/7 (71%) | 38.3±14.9 | 2/3 (67%) | 22.6±6.4 |
| ATP | ||||
| Proportion responders | Δ Firing rate (spikes 20 s−1) | Proportion responders | Δ Firing rate (spikes 20 s−1) | |
| All tissues | 23/26 (88%) | 30.3±5.4 | 2/4 (50%) | 29 |
| Sigmoid colon | 14/16 (88%) | 32.8±7.9 | 1/1 (100%) | – |
| Rectum | 4/4 (100%) | 28.5±13.5 | 0/1 (0%) | – |
Table illustrating single unit responses to VFH probing at 0.07, 0.4 and 2 g, bradykinin or ATP in tissues from patients having surgical resections for cancer, and patients having resections for IBD. The data were presented for all tissue regions studied, sigmoid colon only and rectum only. Mean±SEM; p>0.05; paired t-test.
NS, not significant; VFH, von Frey hair.