Table 1

Relative abundance and prevalence of selected microbial taxa in patients with chronic gastritis and gastric carcinoma in the discovery cohort

Taxa (phylum; class; order; family; genus)Relative abundance (%)*Prevalence (%)†Univariate
OR (95% CI)
Multivariate‡
OR (95% CI)
Chronic gastritisGastric carcinomaP§ Chronic gastritisGastric carcinoma
Proteobacteria; Alphaproteobacteria; Rhizobiales; Phyllobacteriaceae; Phyllobacterium sp.0.25.4<0.000134.664.80.0013.5 (1.7 to 7)3.7 (1.2 to 11)
Proteobacteria; Betaproteobacteria; Burkholderiales; Alcaligenaceae; Achromobacter sp.2.111.1<0.000124.787.0<0.000120.5 (7.4 to 59)56.3 (9.5 to 333)
Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae; Neisseria sp.3.90.4<0.000192.675.9<0.00010.25 (0.09 to 0.7)0.27 (0.1 to 1)
Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter sp.41.75.9<0.000110085.2<0.00010.0 (0.0 to 0.4)NA
Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Citrobacter sp.0.24.3<0.000130.981.5<0.00019.9 (4.3 to 23)6.5 (2.1 to 20)
Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae; Lactobacillus sp.0.0254.7<0.000119.761.1<0.00016.3 (2.9 to 14)3.1 (1.0 to 10)
Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus sp.7.72.9<0.000197.592.60.217NANA
Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium sp.0.0463.7<0.00018.635.2<0.00015.7 (2.2 to 15)7.8 (2.0 to 31)
Actinobacteria; Actinobacteria; Actinomycetales; Nocardiaceae; Rhodococcus sp.0.0023.3<0.00019.931.50.0034.2 (1.7 to 11)3.8 (1.0 to 15)
Bacteroidetes; Bacteroidia; Bacteroidales; Prevotellaceae; Prevotella sp.5.02.0<0.000197.590.70.104NANA
  • *Average relative abundance of specific taxa in subjects containing that taxa.

  • †Percentage of subjects carrying the specific taxa.

  • ‡Multivariate logistic regression analysis with non-carriers as reference adjusted for age and gender.

  • §P values obtained through linear discriminatory analysis effect size (LEfSe).

  • ¶P values obtained by Fisher’s exact test.

  • NA, not assessed.