Outcome measures used in the five cohorts (mean±SD)
| Belgian cohort (n=242) | US cohort 1 (n=243) | US cohort 2 (n=159) | Swedish cohort 1 (n=353) | Swedish cohort 2 (n=147) | |
|---|---|---|---|---|---|
| Pain/discomfort threshold (mm Hg) | 10±4 | 26±13 | 16±8 | 33±13 | 27±8.8 |
| GI symptoms | |||||
| IBS-SSS | 275±91 | 284±92 | 304±90 | 315±91 | |
| GSRS-IBS | 3.5±0.95 | ||||
| DSS | 14±5 | ||||
| Non-GI symptoms | |||||
| SCL-90 som | 0.89±0.71 | ||||
| PHQ-12 | 8.9±4.2 | 7.4±4.0 | 8.5±4.1 | ||
| RPSQ | 11±5.2 | 11±5.4 | |||
| Anxiety | |||||
| HAD | 6.2±4.1 | 7.7±4.6 | 8.5±4.6 | ||
| BSI-18 | 52±11 | 51±9.7 | |||
| Depression | |||||
| HAD | 4.4±3.7 | 5.1±3.7 | 5.3±3.5 | ||
| BSI-18 | 52±9.9 | 53±11 | |||
The sensitivity parameters are displayed as thresholds in mm Hg above the operating pressure for all cohorts except for Swedish cohort 2, as this distension protocol started from 0 mm Hg, whereas all the others distension protocols started from the operating pressure.
Empty cells indicate that this variable was not used in the cohort.
BSI-18, Brief Symptom Inventory-18; DSS, Dyspepsia Symptom Severity Scale; GSRS-IBS, Gastrointestinal Symptom Rating Scale-IBS; HAD, Hospital Anxiety and Depression Scale; IBS-SSS, IBS-Severity Scoring System; PHQ-12, Patient Health Questionnaire 12; RPSQ, Recent Physical Symptoms Questionnaire; SCL-90, Symptom Checklist-90; SCL-90 som, SCL-90 somatisation subscale without GI sx.