Table 3

Association of the 15Phe variant with IBS

CTRLIBS IBS-C IBS-D IBS-M IBS-D/M
AFAFp ValueORAFp ValueORAFp ValueORAFp ValueORAFp ValueOR
Case–control0.2640.306 0.0030* 1.26 0.2790.421.090.312 0.0082 1.30 0.329 0.0026* 1.41 0.319 0.00051* 1.34
PopCol0.290.417 0.045 1.89 0.4000.451.720.4090.201.880.556 0.017 3.81 0.475 0.013 2.50
Combined0.2680.309 0.0013* 1.27 0.2810.391.100.314 0.0052 1.30 0.336 0.00057* 1.46 0.323 0.00012* 1.36
  • *p Value significant after Bonferroni correction for multiple comparisons (N=15), considering five traits (IBS, IBS-C, IBD-D, IBS-M and IBS-D/M) in three datasets (case–control cohorts, PopCol and both combined). Significant p Values (<0.05) highlighted in bold italics.

  • AF, 15Phe allele frequency; CTRL, controls; IBS-C, constipation-predominant IBS; IBS-D, diarrhoea-predominant IBS; IBS-D/M, IBS-D+IBS-M; IBS-M, IBS mixed phenotype; p Value, p Value from logistic regression adjusted for sex and batch (centre).