Table 3

Association of the 15Phe variant with IBS

	CTRL	IBS			IBS-C			IBS-D			IBS-M			IBS-D/M
	AF	AF	p Value	OR	AF	p Value	OR	AF	p Value	OR	AF	p Value	OR	AF	p Value	OR
Case–control	0.264	0.306	0.0030*	*1.26*	0.279	0.42	1.09	0.312	*0.0082*	*1.30*	0.329	0.0026*	*1.41*	0.319	0.00051*	*1.34*
PopCol	0.29	0.417	*0.045*	*1.89*	0.400	0.45	1.72	0.409	0.20	1.88	0.556	*0.017*	*3.81*	0.475	*0.013*	*2.50*
Combined	0.268	0.309	0.0013*	*1.27*	0.281	0.39	1.10	0.314	*0.0052*	*1.30*	0.336	0.00057*	*1.46*	0.323	0.00012*	*1.36*

*p Value significant after Bonferroni correction for multiple comparisons (N=15), considering five traits (IBS, IBS-C, IBD-D, IBS-M and IBS-D/M) in three datasets (case–control cohorts, PopCol and both combined). Significant p Values (<0.05) highlighted in bold italics.
AF, 15Phe allele frequency; CTRL, controls; IBS-C, constipation-predominant IBS; IBS-D, diarrhoea-predominant IBS; IBS-D/M, IBS-D+IBS-M; IBS-M, IBS mixed phenotype; p Value, p Value from logistic regression adjusted for sex and batch (centre).