Case | N | Ctrl | n | BAG4+IL6ST+VWF+CD44*+EGFR* | |||
---|---|---|---|---|---|---|---|
AUC | 95% CI | Sens. (%) | 95% CI | ||||
I | 114 | All ctrls | 386 | 0.79 | 0.74 to 0.85 | 62.3 | 0.54 to 0.71 |
II | 155 | All ctrls | 386 | 0.85 | 0.81 to 0.89 | 71.6 | 0.63 to 0.79 |
III | 147 | All ctrls | 386 | 0.88 | 0.85 to 0.92 | 77.6 | 0.68 to 0.85 |
IV | 98 | All ctrls | 386 | 0.90 | 0.86 to 0.95 | 81.6 | 0.73 to 0.89 |
All cancers | 514 | All ctrls | 386 | 0.86 | 0.83 to 0.88 | 73.0 | 0.68 to 0.78 |
All cancers | 514 | Normal | 168 | 0.84 | 0.81 to 0.87 | 70.0 | 0.62 to 0.75 |
All cancers | 514 | Polyps | 159 | 0.87 | 0.85 to 0.90 | 76.5 | 0.72 to 0.81 |
All cancers | 514 | Colitis | 59 | 0.87 | 0.84 to 0.90 | 73.3 | 0.66 to 0.80 |
*EGFR and CD44's sialyl Lewis-A and Lewis-X information was added to the 5-protein panel. Coefficients were calculated for All cancers versus All ctrls. All ctrls include normal, polyps and colitis samples.
AUC, area under the curve; BAG4, BAG family molecular chaperone regulator 4; EGFR, epidermal growth factor receptor; IL6ST, interleukin-6 receptor subunit beta; ROC, receiver operating characteristic; Sens., sensitivity at 90% specificity; VWF, von Willebrand factor.