Standardised mortality ratios for the Barrett’s oesophagus cohort*, stratified by follow-up time post-Barrett’s oesophagus diagnosis
| 0 to <3 Years | ≥3 to <6 Years | ≥6 Years | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Underlying cause of death (ICD-9 codes; ICD-10 codes) | Observed | Expected | Person-years | SMR (95% CI) | Observed | Expected | Person-years | SMR (95% CI) | Observed | Expected | Person-years | SMR (95% CI) |
| All causes (001-E999; A00-R99,V01-Y89) | 617 | 417.13 | 22 990 | 1.48 (1.36 to 1.60) | 403 | 295.49 | 13 484 | 1.34 (1.23 to 1.50) | 441 | 402.07 | 13 673 | 1.10 (1.00 to 1.20) |
| All causes (001-E999; A00-R99,V01-Y89) excluding oesophageal malignancy (150.0–150.9; C15) | 588 | 413.87 | 22 990 | 1.42 (1.31 to 1.54) | 376 | 293.27 | 13 484 | 1.28 (1.16 to 1.42) | 412 | 399.21 | 13 673 | 1.03 (0.93 to 1.14) |
| Neoplastic mortality (140–239, 273–273.3, 273.9; C00-D48) | 152 | 119.90 | 22 990 | 1.27 (1.07 to 1.49) | 110 | 82.24 | 13 484 | 1.34 (1.10 to 1.61) | 122 | 105.59 | 13 673 | 1.16 (0.96 to 1.38) |
| All neoplasms (140–149, 151–239, 273–273.3, 273.9; C00–C14, C16–D48) excluding oesophageal cancer (150.0–150.9; C15) | 123 | 116.65 | 22 990 | 1.05 (0.88 to 1.26) | 83 | 80.03 | 13 484 | 1.04 (0.83 to 1.29) | 93 | 102.73 | 13 673 | 0.91 (0.73 to 1.11) |
| Malignant neoplasms of the oesophagus (150.0–150.9; C15) | 29 | 3.26 | 22 990 | 8.90 (5.96 to 12.78) | 27 | 2.22 | 13 484 | 12.17 (8.02 to 17.71) | 29 | 2.86 | 13 673 | 10.16 (6.80 to 14.59) |
| Malignant neoplasms of the stomach (151.0–151.9; C16) | 7 | 2.98 | 22 990 | 2.35 (0.94 to 4.84) | 0 | 1.98 | 13 484 | – | 1 | 2.47 | 13 673 | 0.41 (0.01 to 2.26) |
| Malignant neoplasms of the oesophagus (150.0–150.9; C15) or stomach (151.0–151.9; C16, C26.9) | 38 | 6.24 | 22 990 | 6.09 (4.31 to 8.36) | 27 | 4.20 | 13 484 | 6.43 (4.24 to 9.36) | 30 | 5.32 | 13 673 | 5.64 (3.80 to 8.05) |
| Malignant neoplasms of the trachea, bronchus and lung (162.0–162.9; C33–C34) | 25 | 29.72 | 22 990 | 0.84 (0.54 to 1.24) | 16 | 20.06 | 13 484 | 0.80 (0.46 to 1.30) | 24 | 24.47 | 13 673 | 0.98 (0.63 to 1.46) |
| Malignant neoplasms of the colon, rectosigmoid junction and anus (153.0–154.9; C18–C21) | 11 | 10.94 | 22 990 | 1.01 (0.50 to 1.80) | 9 | 7.43 | 13 484 | 1.21 (0.55 to 2.30) | 11 | 9.38 | 13 673 | 1.17 (0.59 to 2.10) |
| Non-neoplastic mortality | ||||||||||||
| Diseases of the circulatory system (390.0–459.9, 93, 94.8, 98.8, 115, 289, 435, 999.1; I00–I99, G45, M30, M31, N28, R58) | 185 | 134.64 | 22 990 | 1.37 (1.18 to 1.59) | 121 | 95.43 | 13 484 | 1.27 (1.05 to 1.52) | 137 | 128.76 | 13 673 | 1.06 (0.89 to 1.26) |
| Acute myocardial infarction (410.00–410.92; I21–I22) | 22 | 25.08 | 22 990 | 0.88 (0.55 to 1.33) | 22 | 17.09 | 13 484 | 1.29 (0.81 to 1.95) | 26 | 21.34 | 13 673 | 1.22 (0.80 to 1.78) |
| Ischaemic heart disease (411.0–414.9, 429.2; I23–25, I20) | 72 | 42.21 | 22 990 | 1.71 (1.33 to 2.15) | 43 | 29.62 | 13 484 | 1.45 (1.05 to 1.96) | 40 | 39.68 | 13 673 | 1.01 (0.72 to 1.37) |
| Cerebrovascular disease (430.0–438.9, 94.87; I60–69, G45) | 33 | 25.18 | 22 990 | 1.31 (0.90 to 1.84) | 19 | 18.01 | 13 484 | 1.06 (0.64 to 1.65) | 19 | 23.31 | 13 673 | 0.82 (0.49 to 1.27) |
| Diseases of the respiratory system (460.00–519.99, 3.22, 12.3, 95.1, 334, 997.3; J00–J99, R09) | 72 | 43.13 | 22 990 | 1.67 (1.31 to 2.10) | 42 | 30.93 | 13 484 | 1.36 (0.98 to 1.84) | 63 | 43.27 | 13 673 | 1.47 (1.12 to 1.86) |
| Diseases of the digestive system (520.00–579.99, 17.8, 32.83, 95.2, 98.86, 99.56, 14.8; K00–K93, R11, R18) | 43 | 13.95 | 22 990 | 3.08 (2.23 to 4.15) | 22 | 9.59 | 13 484 | 2.30 (1.44 to 3.47) | 14 | 12.21 | 13 673 | 1.15 (0.63 to 1.92) |
*Barrett’s oesophagus defined as ICD-9 code 530.85, or 530.2 with SNOMED M73330.
EAR, excess absolute risk; ICD-O, International Classification of Diseases for Oncology; SMR, standardised mortality ratio; SNOMED, Systematised Nomenclature of Medicine.