| B. In-house replication§ | ||||
| Epigenetic mark | Normal tissue eQTLs† | Tumour tissue eQTLs‡ | ||
| Fold enrichment | p Value | Fold enrichment | p Value | |
| PANC-1 | ||||
| H3K4Me1 | 1.41 | 0.0002 | 1.48 | 0.001 |
| H3K4Me3 | 2.57 | <0.0001 | 2.53 | <0.0001 |
| RNA PolII | 0.73 | 1 | 0.77 | 1 |
| hTERT-HPNE | ||||
| H3K4Me1 | 1.11 | 0.1 | 1.19 | 0.001 |
| H3K4Me3 | 2.52 | <0.0001 | 2.43 | <0.0001 |
| RNA PolII | 1.52 | 0.04 | 1.43 | 0.03 |
↵*DNase I hypersensitivity sites and histone modification marks/transcription factor binding sites are based on DNase-seq and ChIP-seq data generated in the PANC-1 pancreatic cancer cell line (PANC-1) and provided by the Encyclopedia of DNA Elements (ENCODE) project.
†cis-eQTLs from the analysis in histologically normal pancreatic tissue samples (LTG).
‡cis-eQTLs from the analysis in pancreatic tumour tissue samples (TCGA/PAAD). The official (UniProt) name for NRSF is REST: RE1-silencing transcription factor; RNA PolII: RNA polymerase II; SIN3A: paired amphipathic helix protein Sin3a; TCF7L2: transcription factor 7-like 2.
§The in-house replication was performed in two pancreatic cell lines: PANC-1 (tumour-derived) and hTERT-HPNE (normal-derived cell line).20
eQTL, expression quantitative trait locus; LTG, Laboratory of Translational Genomics; TCGA, The Cancer Genome Atlas.