Table 2

Performance of different proteins as early-detection plasma markers

	CHS plasma samples					EDRN plasma samples
Proteins	OR	p Value	Q	AUC	Sens. (%)	OR	p Value	q	AUC	Sens. (%)
BAG4	0.642	0.001	0.174	0.66	32.1	0.940	1.89E-08	0.003	0.78	54.2
PIK3CA	0.519	0.001	0.174	0.66	27.8	0.456	0.010	0.014	0.65	25.0
EGFR	0.380	0.012	0.191	0.63	25.6	0.429	0.001	0.004	0.71	34.5
VWF	0.338	0.011	0.191	0.62	25.0	0.419	0.042	0.035	0.61	19.5
UBE2S	0.419	0.003	0.182	0.64	22.8	0.669	2.61E-04	0.003	0.67	41.1
VIP	0.498	0.002	0.176	0.64	22.1	1.043	1.02E-07	0.003	0.79	48.3
CC2D1A	0.408	0.012	0.191	0.62	20.8	0.757	2.86E-06	0.003	0.75	38.7
PHB	0.419	0.014	0.198	0.62	20.5	0.377	0.013	0.016	0.61	22.1
ERCC5	0.451	0.007	0.191	0.62	19.7	0.698	4.34E-04	0.003	0.65	29.7
CD44	0.462	0.005	0.191	0.63	19.2	0.357	0.037	0.032	0.62	21.0
RAB7L1	0.348	0.009	0.191	0.61	19.0	0.619	0.001	0.004	0.66	20.3
LYPD1	0.434	0.002	0.176	0.64	18.4	0.384	0.005	0.009	0.63	22.5
ANKRD6	0.393	0.012	0.191	0.61	18.2	0.483	0.011	0.015	0.66	23.4
IL6ST	0.483	0.015	0.205	0.61	18.1	0.654	0.015	0.018	0.70	20.4
CD4	0.383	0.013	0.191	0.61	17.9	0.415	0.010	0.014	0.63	10.2
CHEK1	0.379	0.009	0.191	0.61	17.7	0.525	0.001	0.005	0.71	35.8
MAPK1	0.373	0.006	0.191	0.62	16.9	0.703	0.008	0.012	0.62	23.5
BRCA1	0.408	0.007	0.191	0.60	16.7	0.599	0.003	0.006	0.70	35.2
GRB2	0.445	0.011	0.191	0.62	16.7	0.426	0.016	0.018	0.64	28.9
MSMB	0.457	0.005	0.191	0.64	16.7	0.394	0.020	0.021	0.60	17.5
FLT3	0.370	0.008	0.191	0.63	15.4	0.409	0.008	0.012	0.69	26.9
BIRC3	0.478	0.002	0.174	0.65	14.1	0.510	0.003	0.006	0.68	32.2
BTG1	0.419	0.007	0.191	0.64	14.1	0.618	0.001	0.004	0.68	39.5
FN1 (Ab2)	0.424	0.012	0.191	0.63	13.9	0.430	0.015	0.018	0.64	16.9
PRL	0.445	0.006	0.191	0.63	13.9	0.760	8.54E-05	0.003	0.74	37.3
WDR1	0.469	0.002	0.174	0.65	13.9	0.499	0.001	0.004	0.65	17.2
SPP1	0.416	0.011	0.191	0.63	13.9	0.547	0.004	0.008	0.66	31.9
FN1 (Ab1)	0.427	0.006	0.191	0.64	13.0	0.451	0.007	0.011	0.72	34.8
GRN	0.400	0.010	0.191	0.64	13.0	0.446	0.001	0.004	0.70	42.1
NAIP	0.410	0.008	0.191	0.63	13.0	0.375	0.027	0.026	0.61	12.1
SV2A	0.405	0.004	0.191	0.65	10.4	0.608	0.001	0.003	0.71	37.4
HOXA3	0.429	0.005	0.191	0.65	9.2	0.444	0.015	0.018	0.65	17.9

Of the 78 markers that met the performance criteria of positive OR, p≤0.015 and AUC>0.60 in the CHS prediagnostic samples, the 32 listed here met our confirmation criteria of a positive OR, p<0.05 and AUC>0.60 in the EDRN samples (120 cases consisting of 30 adenomas, 30 advanced adenomas, 30 stage I–II cancers, 30 stage III–IV cancers and 60 healthy controls). The q value corrects for multiple comparison testing. Sens., sensitivity at 90% specificity. See online supplementary table S3 for M value data.
AUC, area under the curve; CHS, Cardiovascular Health Study; EDRN, Early Detection Research Network.