Table 1

Diagnostic performance of the gamma-glutamyl transpeptidase to platelet ratio (GPR), aspartate aminotransferase to platelet ratio index (APRI), and fibrosis index based on four factors (FIB-4) in a Chinese population with chronic hepatitis B virus (HBV) infection

GPRF0–1 versus F2–4F0–2 versus F3–4F0–3 versus F4
AUROC (95% CI) 0.67 (0.64 to 0.70) 0.70 (0.67 to 0.72) 0.71 (0.68 to 0.73)
 Cut-off values*0.320.320.56
 Sensitivity/specificity (%)40/7847/7936/85
 Correctly classified (%)496172
 PPV/NPV (%)85/3072/5546/78
 Positive/negative LR1.8/0.82.2/0.72.3/0.8
 APRI
AUROC (95% CI) 0.68 (0.65 to 0.71) 0.70 (0.67 to 0.73) 0.66 (0.63 to 0.69)
 Cut-off values†0.51.51.02.0
 Sensitivity/specificity (%)69/5930/8751/7028/82
 Correctly classified (%)67446568
 PPV/NPV (%)84/3888/2938/7937/76
 Positive/negative LR1.7/0.52.4/0.81.7/0.71.6/0.9
 Indeterminate results (%)3715
 FIB-4
AUROC (95% CI) 0.73 (0.70 to 0.76) 0.76 (0.74 to 0.79) 0.77 (0.75 to 0.80)
 Cut-off values‡1.453.25
 Sensitivity/specificity (%)64/7426/93
 Correctly classified (%)6956
 PPV/NPV (%)75/6382/51
 Positive/negative LR2.5/0.53.9/0.8
 Indeterminate results (%)30
 Comparison of AUROCs
 GPR versus APRIp=0.473p=0.768p<0.001
 GPR versus FIB-4p<0.001p<0.001p<0.001
  • *Predetermined cut-off values of GPR were used (0.32 to distinguish significant fibrosis, 0.32 to distinguish extensive fibrosis and 0.56 to distinguish cirrhosis).

  • †Predetermined cut-off values of APRI were used (0.5 and 1.5 to distinguish significant fibrosis, and 1.0 and 2.0 to distinguish cirrhosis).

  • ‡Predetermined cut-off values of FIB-4 were used (1.45 and 3.25 to distinguish extensive fibrosis).

  • APRI, aspartate aminotransferase to platelet ratio index; AUROC, area under the receiver operating characteristic curve; FIB-4, fibrosis index based on four factors; GPR, gamma-glutamyl transpeptidase to platelet ratio; HBV, hepatitis B virus; LR, likelihood ratio; NPV, negative predictive value; PPV, positive predictive value.