Summary of the findings of the literature in local injections of anti-TNF agents in perianal fistulas in CD
| Author | Year | Type of agent | Patients (n) | Fistula closure | Fistula partial response |
| Poggioli G et al 48 | 2005 | IFX | 15 | 66.7% (10/15) | – |
| Asteria et al 49 | 2006 | IFX | 11 | 36.4% (4/11) | 72.7% (8/11) |
| Alessandroni et al 15 | 2011 | IFX | 12 (4 excluded) | 87.5% (7/8) | – |
| Tonelli et al 50 | 2013 | ADA | 12 | 75% (9/12) | 25% (3/12) |
ADA, adalimumab; IFX , infliximab.