Table 3

Covariates associated with future risk of death or liver transplantation in the PSC derivation cohort

	Univariate analysis		Multivariable analysis (adjusted for platelet count and serum albumin)*		Multivariable analysis (adjusted for cirrhosis)*
	Unadjusted HR (95% CI)	p Value	Adjusted HR (95% CI)	p Value	Adjusted HR (95% CI)	p Value
Elevated serum AST (per IU/L increase)†	1.01 (1.00 to 1.01)	0.006	1.01 (1.00 to 1.02)	0.003	1.02 (1.01 to 1.02)	<0.001
Ascending cholangitis	2.62 (1.20 to 5.72)	0.016	3.40 (1.46 to 7.90)	0.004	4.23 (1.72 to 10.42)	0.002
Antibiotic exposure	1.91 (1.24 to 2.92)	0.003	NS	NS	NS	NS
Cirrhosis	6.02 (1.83 to 20.00)	0.003	N/A	N/A	7.69 (2.04 to 27.03)	0.002
Elevated serum bilirubin (per g/L increase)†	1.02 (1.012 to 1.03)	<0.001	NS	NS	N/A
Thrombocytopenia (per 50×10³ cells decrease)†	1.22 (1.02 to 1.42)	0.028	NS	NS	N/A
Hypoalbuminaemia (per g/L decrease)†	1.21 (1.12 to 1.30)	<0.001	1.18 (1.08 to 1.28)	<0.001	N/A
sVAP-1 (per 100 ng increase)†	1.11 (1.11 to 1.22)	0.002	(Not included)		(Not included)
sVAP-1: >529 ng/mL	3.76 (1.68 to 8.47)	0.001	2.70 (1.03 to 714)	0.043	3.85 (1.57 to 9.34)	0.003

*As platelet count and hypoalbuminaemia were used in defining cirrhosis as a covariate, their impact was determined on a singular as well as collective level in a stepwise multivariable Cox regression model.
†Values in parenthesis indicate that the degree of risk (HR in the adjacent columns) increases according to a unit change in the given variable.
AST, aspartate transaminase; NA, not applicable; NS, not significant; PSC, primary sclerosing cholangitis; VAP, vascular adhesion protein.