Cumulative incidence colon and sigmoidal-rectal cancer stratified by age, path_MMR variant and gender. There was no observed colon or sigmoid-rectal cancer in path_PMS2 carriers in any age group (see table 3)
| Age | Cumulative incidence by age (% (95% CI)) | ||||||
| path_MLH1 | path_MSH2 | path_MSH6 | |||||
| Females | Males | Females | Males | Females | Males | ||
| Colon cancer (ICD9=153) | 40 | 10.4 (5.2 to 15.6) | 15.4 (9.0 to 21.9) | 10.1 (2.9 to 17.3) | 7.4 (1.2 to 13.6) | 0 | 0 |
| 50 | 18.8 (12.6to 25.0) | 33.3 (25.5 to 41.1) | 23.8 (14.8 to 32.8) | 15.8 (7.2 to 24.3) | 0 | ||
| 60 | 28.1 (20.9 to 35.2) | 45.2 (36.6 to 53.8)* | 31.4 (21.9 to 41.0) | 21.5 (11.3 to 31.6) | |||
| 70 | 37.3 (28.5 to 46.1) | 45.2 (36.6 to 53.8) | 44.7 (33.7 to 55.7) | 32.4 (17.7 to 47.2) | |||
| 75 | 42.1 (31.8 to 52.5) | 50.8 (40.1 to 61.5) | 44.7 (33.7 to 55.7) | 42.6 (20.4 to 64.9) | |||
| Sigmoid- rectal cancer(ICD9=154) | 40 | 1.4 (0.0 to 3.3) | 1.9 (0.0 to 4.1) | 0 | 1.3 (0.0 to 3.8) | 0 | 0 |
| 50 | 2.9 (0.3 to 5.4) | 3.6 (0.8 to 6.4) | 1.0 (0.0 to 3.0) | 8.9 (3.0 to 14.7) | 0 | 0 | |
| 60 | 6.1 (2.4 to 9.8) | 6.5 (2.6 to 10.5) | 4.0 (0.2 to 7.8) | 17.9 (9.2 to 26.5) | 4.6 (0.0 to 10.7) | 0 | |
| 70 | 10.2 (4.9 to 15.6) | 7.6 (3.2 to 12.1) | 8.2 (2.2 to 14.3) | 20.7 (10.7 to 30.7) | 7.0to (0.0 to 14.6) | 0 | |
| 75 | 11.7 (5.7 to 17.7) | 11.7 (4.7 to 18.7) | 12.9 (4.4 to 21.3) | 26.0 (12.3 to 39.7) | 7.0 (0.0 to 14.6) | 0 | |
*Increased (p<0.05) compared with same-aged females.
**Lower (p<0.05) than in path_MLH1 or path_MSH2 carrier with same gender and age.