Relative cumulative incidence (RR) cancer at 75 years in carriers of path_MMR genes stratified by gene. 95% CIs are shown in parentheses. Significantly increased (p<0.05) RRs are highlighted in bold. Maximum RR by gene underlined
| ICD9 | Organ | Population incidence (%) | Relative cumulative incidence (95% CI) | |||
| path_MLH1 | path_MSH2 | path_MSH6 | path_PMS2 | |||
| Any cancer | 24.4 | 3.1 (2.8 to 3.4) | 3.3 (2.9 to 3.7) | 2.5 (1.7 to 3.2) | 2.1 (0 to 4.1) | |
| In separate organs order by RR | ||||||
| 152 | Duodenum | 0.1 | 64.7 (27.4 to 102.1) | 20.1 (0.6 to 39.6) | 0 | 0 |
| 182 | Endometrium | 1.6 | 26.7 (20.7 to 32.7) | 35.5 (26.1 to 44.8) | 28.9 (17.1 to 40.6) | 16.5 (0.5 to 32.4) |
| 153 | Colon | 2.1 | 22.3 (18.7 to 25.9) | 20.2 (15.6 to 24.7) | 6.8 (1.5 to 12.1) | 0 |
| 156 | Bile duct and gall bladder | 0.2 | 18.7 (6.3 to 31.1) | 8.6 (0 to 25.4) | 0 | 0 |
| 183 | Ovary | 1.0 | 10.1 (4.8 to 15.4) | 16.9 (5.7 to 28.0) | 13.1 (0 to 31.2) | 0 |
| 189 | Ureter and kidney | 1.3 | 3.5 (1.2 to 5.9) | 13.7 (8.2 to 19.2) | 2.3 (0 to 5.4) | 0 |
| 154 | Sigmoid and rectum | 1.4 | 8.4 (5.2 to 11.7) | 13.0 (7.8 to 18.3) | 3.3 (0 to 6.9) | 0 |
| 191 | Brain | 0.5 | 1.9 (0 to 4.8) | 10.5 (0.4 to 20.6) | 2.9 (0 to 8.4) | 0 |
| 151 | Stomach | 0.8 | 8.9 (4.4 to 13.4) | 9.7 (2.3 to 17.0) | 6.6 (0 to 16.4) | 0 |
| 188 | Urine bladder | 1.0 | 4.1 (1.5 to 6.7) | 8.1 (2.8 to 13.3) | 8.2 (0 to 16.9) | 0 |
| 157 | Pancreas | 0.8 | 7.8 (3.3 to 12.3) | 0.6 (0 to 1.9) | 1.8 (0 to 5.2) | 0 |
| 185 | Prostate | 10 | 1.7 (0.9 to 2.7) | 3.2 (1.2 to 5.1) | 1.8 (0 to 4.4) | 3.8 (0 to 9.6) |
| 174 | Breast | 9.4 | 1.3 (0.7 to 1.8) | 1.2 (0.5 to 2.0) | 1.4 (0.2 to 2.6) | 6.0 (0 to 10.6) |
| In anatomical regions ordered by RR | ||||||
| Gynaecological | 2.6 | 19.1 (15.6 to 22.7) | 25.3 (20.1 to 30.4) | 20.8 (13.3 to 28.2) | 10.1 (0.3 to 20) | |
| Colorectal | 3.8 | 12.1 (10 to 14.2) | 11.3 (8.7 to 13.9) | 3.9 (0.9 to 7.0) | 0 | |
| Upper gastrointestinal cancer | 1.9 | 11.2 (8.2 to 14.3) | 5.4 (2.1 to 8.6) | 3.5 (0 to 7.8) | 0 | |
| Urinary tract cancer | 2.3 | 3.5 (1.9 to 5.1) | 10.8 (7.2 to 14.4) | 4.8 (0.7 to 8.8) | 0 | |