Cumulative incidences of individual cancers in carriers of path_MMR variants in the different genes from 25 years of age up to the age of 75 are shown. Incidence of breast, endometrial and ovarian cancers were calculated in females and incidence of prostate cancers calculated in men; all others in both genders combined
| ICD9 | Organ | Age | Cumulative incidence by age (% (95% CI)) | |||
| path_MLH1 | path_MSH2 | path_MSH6 | path_PMS2 | |||
| Colorectal cancer | ||||||
| 153 | Colon | 40 | 12.9 (8.8 to 17.1) | 8.6 (3.9 to 13.3) | 0 | 0 |
| 50 | 25.7 (20.7 to 30.7) | 20.2 (13.9 to 26.4) | 1.8 (0.0 to 5.2) | 0 | ||
| 60 | 36.0 (30.4 to 41.6) | 27.3 (20.3 to 34.3) | 5.3 (0.0 to 11.2) | 0 | ||
| 70 | 41.6 (35.2 to 48.0) | 40.2 (31.3 to 49.1) | 14.2 (3.1 to 25.4) | 0 | ||
| 75 | 46.7 (39.2 to 54.3) | 42.4 (32.9 to 51.9) | 14.2 (3.1 to 25.4) | 0 | ||
| 154 | Sigmoid and rectum | 40 | 1.6 (0.2 to 3.0) | 0.6 (0.0 to 1.8) | 0 | 0 |
| 50 | 3.2 (1.3 to 5.0) | 4.7 (1.7 to 7.7) | 0 | 0 | ||
| 60 | 6.3 (3.6 to 9.0) | 9.8 (5.5 to 14.1) | 3.0 (0.0 to 7.1) | 0 | ||
| 70 | 9.2 (5.6 to 12.9) | 13.5 (8.0 to 19.0) | 4.6 (0.0 to 9.7) | 0 | ||
| 75 | 11.8 (7.2 to 16.4) | 18.3 (10.9 to 25.6) | 4.6 (0.0 to 9.7) | 0 | ||
| Endometrial and ovarian cancer | ||||||
| 182 | Endometrium | 40 | 3.1 (0.4 to 5.8) | 1.5 (0.0 to 4.4) | 0 | 0 |
| 50 | 18.7 (12.9 to 24.5) | 15.9 (7.9 to 23.8) | 15.4 (4.1 to 26.8) | 0 | ||
| 60 | 34.8 (27.1 to 42.5) | 40.9 (29.2 to 52.6) | 33.2 (16.5 to 49.9) | 26.4 (0.8 to 51.9) | ||
| 70 | 40.3 (31.5 to 49.1) | 52.7 (38.7 to 66.8) | 46.2 (27.3 to 65.0) | 26.4 (0.8 to 51.9) | ||
| 75 | 42.7 (33.1 to 52.3) | 56.7 (41.8 to 71.6) | 46.2 (27.3 to 65.0) | 26.4 (0.8 to 51.9) | ||
| 183 | Ovaries | 40 | 2.6 (0.1 to 5.2) | 3.8 (0.0 to 8.0) | 4.2 (0.0 to 12.3) | 0 |
| 50 | 6.8 (2.9 to 10.7) | 10.7 (4.1 to 17.4) | 4.2 (0.0 to 12.3) | 0 | ||
| 60 | 8.6 (4.0 to 13.2) | 12.3 (5.1 to 19.5) | 4.2 (0.0 to 12.3) | 0 | ||
| 70 | 10.1 (4.8 to 15.4) | 16.9 (5.7 to 28.0) | 13.1 (0.0 to 31.2) | 0 | ||
| 75 | 10.1 (4.8 to 15.4) | 16.9 (5.7 to 28.0) | 13.1 (0.0 to 31.2) | 0 | ||
| Upper gastrointestinal cancer | ||||||
| 151 | Stomach | 40 | 0.3 (0.0 to 0.9) | 0 | 0 | 0 |
| 50 | 0.8 (0.0 to 1.7) | 0.5 (0.0 to 1.4) | 0 | 0 | ||
| 60 | 2.4 (0.7 to 4.0) | 1.6 (0.0 to 3.4) | 1.4 (0.0 to 4.2) | 0 | ||
| 70 | 6.3 (3.0 to 9.7) | 4.1 (0.8 to 7.5) | 1.4 (0.0 to 4.2) | 0 | ||
| 75 | 7.1 (3.5 to 10.8) | 7.7 (1.9 to 13.6) | 5.3 (0.0 to 13.1) | 0 | ||
| 152 | Duodenum | 40 | 0.4 (0.0 to 1.1) | 0 | 0 | 0 |
| 50 | 1.1 (0.0 to 2.3) | 1.0 (0.0 to 2.3) | 0 | 0 | ||
| 60 | 2.1 (0.5 to 3.7) | 2.0 (0.1 to 4.0) | 0 | 0 | ||
| 70 | 4.1 (1.4 to 6.8) | 2.0 (0.1 to 4.0) | 0 | 0 | ||
| 75 | 6.5 (2.7 to 10.2) | 2.0 (0.1 to 4.0) | 0 | 0 | ||
| 156 | Bile duct and gall bladder | 40 | 0 | 0 | 0 | 0 |
| 50 | 0.3 (0.0 to 0.8) | 0 | 0 | 0 | ||
| 60 | 1.3 (0.0 to 2.5) | 0 | 0 | 0 | ||
| 70 | 3.7 (1.3 to 6.2) | 0 | 0 | 0 | ||
| 75 | 3.7 (1.3 to 6.2) | 1.7 (0.0 to 5.1) | 0 | 0 | ||
| 157 | Pancreas | 40 | 0.3 (0.0 to 0.9) | 0 | 0 | 0 |
| 50 | 1.1 (0.0 to 2.1) | 0 | 0 | 0 | ||
| 60 | 1.7 (0.3 to 3.1) | 0.5 (0.0 to 1.5) | 1.4 (0.0 to 4.2) | 0 | ||
| 70 | 3.9 (1.4 to 6.4) | 0.5 (0.0 to 1.5) | 1.4 (0.0 to 4.2) | 0 | ||
| 75 | 6.2 (2.6 to 9.8) | 0.5 (0.0 to 1.5) | 1.4 (0.0 to 4.2) | 0 | ||
| Urinary tract cancer | ||||||
| 188 | Urinary bladder | 40 | 0 | 0 | 0 | 0 |
| 50 | 0.5 (0.0 to 1.2) | 1.0 (0.0 to 2.3) | 2.9 (0.0 to 7.0) | 0 | ||
| 60 | 1.9 (0.4 to 3.4) | 3.6 (1.0 to 6.3) | 4.3 (0.0 to 9.1) | 0 | ||
| 70 | 4.1 (1.5 to 6.7) | 6.2 (2.3 to 10.2) | 4.3 (0.0 to 9.1) | 0 | ||
| 75 | 4.1 (1.5 to 6.7) | 8.1 (2.8 to 13.3) | 8.2 (0.0 to 16.9) | 0 | ||
| 189 | Ureter and kidney | 40 | 0.3 (0.0 to 0.9) | 0 | 0 | 0 |
| 50 | 0.8 (0.0 to 1.8) | 2.4 (0.3 to 4.5) | 0 | 0 | ||
| 60 | 1.1 (0.0 to 2.2) | 6.9 (3.3 to 10.5) | 1.4 (0.0 to 4.2) | 0 | ||
| 70 | 3.8 (1.2 to 6.4) | 16.0 (9.6 to 22.4) | 3.0 (0.0 to 7.0) | 0 | ||
| 75 | 4.6 (1.6 to 7.6) | 17.8 (10.6 to 25.0) | 3.0 (0.0 to 7.0) | 0 | ||
| Other LS or possible LS cancers | ||||||
| 174 | Breast | 40 | 0 | 2.6 (0.0 to 6.2) | 0 | 0 |
| 50 | 2.9 (0.6 to 5.2) | 5.2 (0.7 to 9.8) | 0 | 0 | ||
| 60 | 8.3 (4.2 to 12.4) | 6.1 (1.3 to 11.0) | 4.7 (0.0 to 11.0) | 8.6 (0.0 to 24.8) | ||
| 70 | 12.0 (6.7 to 17.3) | 11.5 (4.6 to 18.4) | 13.3 (2.2 to 24.4) | 8.6 (0.0 to 24.8) | ||
| 75 | 12.0 (6.7 to 17.3) | 11.5 (4.6 to 18.4) | 13.3 (2.2 to 24.4) | 55.9 (0.0 to 100.0) | ||
| 185 | Prostate | 40 | 0 | 0 | 0 | 0 |
| 50 | 0.6 (0.0 to 1.6) | 0 | 0 | 37.9 (0.0 to 95.9) | ||
| 60 | 5.3 (1.4 to 9.1) | 4.2 (0.0 to 8.8) | 0 | 37.9 (0.0 to 95.9) | ||
| 70 | 13.3 (6.1 to 20.4) | 13.2 (3.7 to 6.1) | 4.4 (0.0 to 12.9) | 37.9 (0.0 to 95.9) | ||
| 75 | 16.9 (8.5 to 25.3) | 31.6 (11.7 to 51.5) | 18.3 (0.0 to 44.4) | 37.9 (0.0 to 95.9) | ||
| 191 | Brain | 40 | 0.3 (0.0 to 0.9) | 0 | 0 | 0 |
| 50 | 0.3 (0.0 to 0.9) | 0 | 0 | 0 | ||
| 60 | 0.3 (0.0 to 0.9) | 1.1 (0.0 to 2.6) | 1.4 (0.0 to 4.2) | 0 | ||
| 70 | 1.0 (0.0 to 2.4) | 1.9 (0.0 to 4.0) | 1.4 (0.0 to 4.2) | 0 | ||
| 75 | 1.0 (0.0 to 2.4) | 5.3 (0.2 to 10.3) | 1.4 (0.0 to 4.2) | 0 | ||
LS, Lynch syndrome